Current understanding of mycobacterium abscessus infection

Go Eun Choi, Youngsuk Jo, Sung Jae Shin

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) that cause a broad spectrum of infections in humans. In addition, the association of M. abscessus with the cause of community- and hospital-acquired infections has been recently reported. In fact, M. abscessus is known to be the most drug-resistant mycobacterium and naturally resistant to first-line anti-tuberculous drugs, resulting in the limited therapeutic options and a high failure rate of treatment response. Three closely related species; M. abscessus (sensu stricto), M. bolletii, and M. massiliense are currently identified however, consensus on the naming of M. abscessus-related species has not been made to date. We herein discuss the advanced understanding of the virulence potentials and pathophysiological features of M. abscessus to establish novel therapeutic strategies for M. abscessus infection.

Original languageEnglish
Pages (from-to)17-28
Number of pages12
JournalJournal of Bacteriology and Virology
Volume42
Issue number1
DOIs
Publication statusPublished - 2012 Mar

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Mycobacterium Infections
Mycobacterium
Community-Acquired Infections
Community Hospital
Cross Infection
Infection
Treatment Failure
Pharmaceutical Preparations
Virulence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

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abstract = "Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) that cause a broad spectrum of infections in humans. In addition, the association of M. abscessus with the cause of community- and hospital-acquired infections has been recently reported. In fact, M. abscessus is known to be the most drug-resistant mycobacterium and naturally resistant to first-line anti-tuberculous drugs, resulting in the limited therapeutic options and a high failure rate of treatment response. Three closely related species; M. abscessus (sensu stricto), M. bolletii, and M. massiliense are currently identified however, consensus on the naming of M. abscessus-related species has not been made to date. We herein discuss the advanced understanding of the virulence potentials and pathophysiological features of M. abscessus to establish novel therapeutic strategies for M. abscessus infection.",
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Current understanding of mycobacterium abscessus infection. / Choi, Go Eun; Jo, Youngsuk; Shin, Sung Jae.

In: Journal of Bacteriology and Virology, Vol. 42, No. 1, 03.2012, p. 17-28.

Research output: Contribution to journalReview article

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