Curved biodegradable microneedles for vascular drug delivery

Chang Kuk Choi, Jin Bum Kim, Eui Hwa Jang, Young Nam Youn, WonHyoung Ryu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

Original languageEnglish
Pages (from-to)2483-2488
Number of pages6
JournalSmall
Volume8
Issue number16
DOIs
Publication statusPublished - 2012 Aug 20

Fingerprint

Drug delivery
Blood Vessels
Blood vessels
Pharmaceutical Preparations
Hyperplasia
Atherosclerosis
Arteries
Hot Temperature
Annealing
Tissue
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Choi, C. K., Kim, J. B., Jang, E. H., Youn, Y. N., & Ryu, W. (2012). Curved biodegradable microneedles for vascular drug delivery. Small, 8(16), 2483-2488. https://doi.org/10.1002/smll.201200441
Choi, Chang Kuk ; Kim, Jin Bum ; Jang, Eui Hwa ; Youn, Young Nam ; Ryu, WonHyoung. / Curved biodegradable microneedles for vascular drug delivery. In: Small. 2012 ; Vol. 8, No. 16. pp. 2483-2488.
@article{5bba800f80c34af79e181d3d765050de,
title = "Curved biodegradable microneedles for vascular drug delivery",
abstract = "Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.",
author = "Choi, {Chang Kuk} and Kim, {Jin Bum} and Jang, {Eui Hwa} and Youn, {Young Nam} and WonHyoung Ryu",
year = "2012",
month = "8",
day = "20",
doi = "10.1002/smll.201200441",
language = "English",
volume = "8",
pages = "2483--2488",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "16",

}

Choi, CK, Kim, JB, Jang, EH, Youn, YN & Ryu, W 2012, 'Curved biodegradable microneedles for vascular drug delivery', Small, vol. 8, no. 16, pp. 2483-2488. https://doi.org/10.1002/smll.201200441

Curved biodegradable microneedles for vascular drug delivery. / Choi, Chang Kuk; Kim, Jin Bum; Jang, Eui Hwa; Youn, Young Nam; Ryu, WonHyoung.

In: Small, Vol. 8, No. 16, 20.08.2012, p. 2483-2488.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Curved biodegradable microneedles for vascular drug delivery

AU - Choi, Chang Kuk

AU - Kim, Jin Bum

AU - Jang, Eui Hwa

AU - Youn, Young Nam

AU - Ryu, WonHyoung

PY - 2012/8/20

Y1 - 2012/8/20

N2 - Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

AB - Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

UR - http://www.scopus.com/inward/record.url?scp=84864694818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864694818&partnerID=8YFLogxK

U2 - 10.1002/smll.201200441

DO - 10.1002/smll.201200441

M3 - Article

VL - 8

SP - 2483

EP - 2488

JO - Small

JF - Small

SN - 1613-6810

IS - 16

ER -