Curved biodegradable microneedles for vascular drug delivery

Chang Kuk Choi, Jin Bum Kim, Eui Hwa Jang, Young Nam Youn, Won Hyoung Ryu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

Original languageEnglish
Pages (from-to)2483-2488
Number of pages6
JournalSmall
Volume8
Issue number16
DOIs
Publication statusPublished - 2012 Aug 20

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Choi, C. K., Kim, J. B., Jang, E. H., Youn, Y. N., & Ryu, W. H. (2012). Curved biodegradable microneedles for vascular drug delivery. Small, 8(16), 2483-2488. https://doi.org/10.1002/smll.201200441