Cutaneous overlap syndrome

J. S. Lee, K. H. Lee, S. C. Kim, S. H. Lee

Research output: Contribution to journalArticlepeer-review


We report two cases of cutaneous overlap syndrome in a 30-year-old woman and a 63-year-old woman. Histologically two cases showed characteristic findings of morphea and LE simultaneously in the same lesion. In case 1, direct immunofluorescence findings showed granular deposits of IgM, IgG, IgA along the dermoepidermal junction, and anti nuclear antibody test showed 1:80 positive finding. In case 2, direct immunofluorescence findings were negative, but histopathologic findings showed distinct hydropic degeneration of basal cell layer and thickening of basement membrane zone with the characteristic findings of morphea. For the treatment, oral prednisolone (10 mg/day), intralesional triamcinolone injection and hydroxychloroquine (200 mg/day), intralesional triamcinolone injection were performed respectively, but both cases were not much improved.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalKorean Journal of Dermatology
Issue number2
Publication statusPublished - 1995

Bibliographical note

Funding Information:
Acknowledgment: This study was supported by grants P01 CA 12.582 and T32 CA 09.689 from the National Cancer Institute and by funding from the Wayne and Gladys Valley Foundation, Oakland, CA; the Rogovin-Davidow Foundation, Los Angeles, CA; and the Rod Fasone Memorial Cancer Research Fund, Indianapolis, IN.

All Science Journal Classification (ASJC) codes

  • Dermatology


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