Cutaneous overlap syndrome

We report two cases of cutaneous overlap syndrome in a 30-year-old woman and a 63-year-old woman. Histologically two cases showed characteristic findings of morphea and LE simultaneously in the same lesion. In case 1, direct immunofluorescence findings showed granular deposits of IgM, IgG, IgA along the dermoepidermal junction, and anti nuclear antibody test showed 1:80 positive finding. In case 2, direct immunofluorescence findings were negative, but histopathologic findings showed distinct hydropic degeneration of basal cell layer and thickening of basement membrane zone with the characteristic findings of morphea. For the treatment, oral prednisolone (10 mg/day), intralesional triamcinolone injection and hydroxychloroquine (200 mg/day), intralesional triamcinolone injection were performed respectively, but both cases were not much improved.