We report two cases of cutaneous overlap syndrome in a 30-year-old woman and a 63-year-old woman. Histologically two cases showed characteristic findings of morphea and LE simultaneously in the same lesion. In case 1, direct immunofluorescence findings showed granular deposits of IgM, IgG, IgA along the dermoepidermal junction, and anti nuclear antibody test showed 1:80 positive finding. In case 2, direct immunofluorescence findings were negative, but histopathologic findings showed distinct hydropic degeneration of basal cell layer and thickening of basement membrane zone with the characteristic findings of morphea. For the treatment, oral prednisolone (10 mg/day), intralesional triamcinolone injection and hydroxychloroquine (200 mg/day), intralesional triamcinolone injection were performed respectively, but both cases were not much improved.
|Number of pages||5|
|Journal||Korean Journal of Dermatology|
|Publication status||Published - 1995|
Bibliographical noteFunding Information:
Acknowledgment: This study was supported by grants P01 CA 12.582 and T32 CA 09.689 from the National Cancer Institute and by funding from the Wayne and Gladys Valley Foundation, Oakland, CA; the Rogovin-Davidow Foundation, Los Angeles, CA; and the Rod Fasone Memorial Cancer Research Fund, Indianapolis, IN.
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