CVD-grown monolayer MoS 2 in bioabsorbable electronics and biosensors

Xiang Chen, Yong Ju Park, Minpyo Kang, Seung Kyun Kang, Jahyun Koo, Sachin M. Shinde, Jiho Shin, Seunghyun Jeon, Gayoung Park, Ying Yan, Matthew R. MacEwan, Wilson Z. Ray, Kyung Mi Lee, John A. Rogers, Jong-Hyun Ahn

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS 2 , including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models. The results show that MoS 2 undergoes hydrolysis slowly in aqueous solutions without adverse biological effects. We also present a class of MoS 2 -based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models. Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Our findings support the broader use of 2D materials in transient electronics and qualitatively expand the design options in other areas.

Original languageEnglish
Article number1690
JournalNature communications
Volume9
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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animal models
Biosensing Techniques
bioinstrumentation
Biosensors
Chemical vapor deposition
Monolayers
Animals
Electronic equipment
Animal Models
vapor deposition
brain damage
Technology
biological effects
sensors
Recovery of Function
Sensors
Intracranial Pressure
biocompatibility
Cytotoxicity
Biocompatibility

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Chen, Xiang ; Park, Yong Ju ; Kang, Minpyo ; Kang, Seung Kyun ; Koo, Jahyun ; Shinde, Sachin M. ; Shin, Jiho ; Jeon, Seunghyun ; Park, Gayoung ; Yan, Ying ; MacEwan, Matthew R. ; Ray, Wilson Z. ; Lee, Kyung Mi ; Rogers, John A. ; Ahn, Jong-Hyun. / CVD-grown monolayer MoS 2 in bioabsorbable electronics and biosensors In: Nature communications. 2018 ; Vol. 9, No. 1.
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Chen, X, Park, YJ, Kang, M, Kang, SK, Koo, J, Shinde, SM, Shin, J, Jeon, S, Park, G, Yan, Y, MacEwan, MR, Ray, WZ, Lee, KM, Rogers, JA & Ahn, J-H 2018, ' CVD-grown monolayer MoS 2 in bioabsorbable electronics and biosensors ', Nature communications, vol. 9, no. 1, 1690. https://doi.org/10.1038/s41467-018-03956-9

CVD-grown monolayer MoS 2 in bioabsorbable electronics and biosensors . / Chen, Xiang; Park, Yong Ju; Kang, Minpyo; Kang, Seung Kyun; Koo, Jahyun; Shinde, Sachin M.; Shin, Jiho; Jeon, Seunghyun; Park, Gayoung; Yan, Ying; MacEwan, Matthew R.; Ray, Wilson Z.; Lee, Kyung Mi; Rogers, John A.; Ahn, Jong-Hyun.

In: Nature communications, Vol. 9, No. 1, 1690, 01.12.2018.

Research output: Contribution to journalArticle

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AU - Shinde, Sachin M.

AU - Shin, Jiho

AU - Jeon, Seunghyun

AU - Park, Gayoung

AU - Yan, Ying

AU - MacEwan, Matthew R.

AU - Ray, Wilson Z.

AU - Lee, Kyung Mi

AU - Rogers, John A.

AU - Ahn, Jong-Hyun

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N2 - Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS 2 , including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models. The results show that MoS 2 undergoes hydrolysis slowly in aqueous solutions without adverse biological effects. We also present a class of MoS 2 -based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models. Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Our findings support the broader use of 2D materials in transient electronics and qualitatively expand the design options in other areas.

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