Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: Decoration of the pyridine unit

Jin Ho Lee, Ikyon Kim

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A new synthetic route to indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of indolizines. In particular, Suzuki-Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton.

Original languageEnglish
Pages (from-to)1283-1288
Number of pages6
JournalJournal of Organic Chemistry
Volume78
Issue number3
DOIs
Publication statusPublished - 2013 Feb 1

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Indolizines
Derivatives
Acids
2-acetylpyrrole
pyridine

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles : Decoration of the pyridine unit. / Lee, Jin Ho; Kim, Ikyon.

In: Journal of Organic Chemistry, Vol. 78, No. 3, 01.02.2013, p. 1283-1288.

Research output: Contribution to journalArticle

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