Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Most kaempferol derivatives showed statistically significant antiviral activities against HRV1B-infected cells. Among the tested compounds, kaempferol-3-O-[2″,6″-di-O-Z-p-coumaroyl]-β-D-glucopyranoside exhibited the most consistent and effective antiviral activities against all infections.
Bibliographical noteFunding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea.
© 2018 Elsevier Ltd
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Plant Science