Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata

Nanyoung Kim; Seon Ju Park; Nguyen Xuan Nhiem; Jae Hyoung Song; Hyun Jeong Ko; Seung Hyun Kim

doi:10.1016/j.phytochem.2018.11.001

Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata

Nanyoung Kim, Seon Ju Park, Nguyen Xuan Nhiem, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Most kaempferol derivatives showed statistically significant antiviral activities against HRV1B-infected cells. Among the tested compounds, kaempferol-3-O-[2″,6″-di-O-Z-p-coumaroyl]-β-D-glucopyranoside exhibited the most consistent and effective antiviral activities against all infections.

Original language	English
Pages (from-to)	135-141
Number of pages	7
Journal	Phytochemistry
Volume	158
DOIs	https://doi.org/10.1016/j.phytochem.2018.11.001
Publication status	Published - 2019 Feb

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea.

Publisher Copyright:
© 2018 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2018.11.001

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title = "Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata",

abstract = "Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Most kaempferol derivatives showed statistically significant antiviral activities against HRV1B-infected cells. Among the tested compounds, kaempferol-3-O-[2″,6″-di-O-Z-p-coumaroyl]-β-D-glucopyranoside exhibited the most consistent and effective antiviral activities against all infections.",

author = "Nanyoung Kim and Park, {Seon Ju} and Nhiem, {Nguyen Xuan} and Song, {Jae Hyoung} and Ko, {Hyun Jeong} and Kim, {Seung Hyun}",

note = "Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = feb,

doi = "10.1016/j.phytochem.2018.11.001",

language = "English",

volume = "158",

pages = "135--141",

journal = "Phytochemistry",

issn = "0031-9422",

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T1 - Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata

AU - Kim, Nanyoung

AU - Park, Seon Ju

AU - Nhiem, Nguyen Xuan

AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

N1 - Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2019/2

Y1 - 2019/2

N2 - Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Most kaempferol derivatives showed statistically significant antiviral activities against HRV1B-infected cells. Among the tested compounds, kaempferol-3-O-[2″,6″-di-O-Z-p-coumaroyl]-β-D-glucopyranoside exhibited the most consistent and effective antiviral activities against all infections.

AB - Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Most kaempferol derivatives showed statistically significant antiviral activities against HRV1B-infected cells. Among the tested compounds, kaempferol-3-O-[2″,6″-di-O-Z-p-coumaroyl]-β-D-glucopyranoside exhibited the most consistent and effective antiviral activities against all infections.

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JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

ER -

Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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