Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria

Jee Min Park, Sung Chul Won, Jae Il Shin, Hyunee Yim, Ki Soo Pai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To evaluate the therapeutic role of cyclosporin A (CyA) for the treatment of Henoch-Schönlein nephritis (HSN), 29 patients (18 boys, 11 girls) with nephrotic-range proteinuria were analyzed retrospectively. Mean age was 8.6 years (range 2.0-15.5 years) at diagnosis of Henoch-Schönlein purpura (HSP). All patients had developed the nephrotic-range proteinuria at a mean interval of 4.4 months (range 0-50.7 months) after the diagnosis of HSP. Mean duration of CyA treatment was 12.3 months (range 2.6-55.0 months). Mean follow-up times were 3.7 years (range 1.2-12.9 years) from the beginning of the CyA treatment. Steroids were tapered off and stopped gradually after initiation of CyA. All patients responded to the CyA treatment within a mean of 1.8 months (range 1 week to 3.5 months). Twenty-three patients achieved stable remission with mean follow-up duration of 3.2 years and 6 patients seemed to become CyA-dependent, since they developed proteinuria when the treatment was stopped. Renal function was preserved in all patients but one who developed end-stage renal disease after poor compliance with CyA. We concluded that CyA treatment for HSN showing nephrotic-range proteinuria is very effective and a safe method, although some patients become CyA-dependent.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalPediatric Nephrology
Volume26
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

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Nephritis
Proteinuria
Cyclosporine
Schoenlein-Henoch Purpura
Therapeutics
Chronic Kidney Failure
Steroids
Kidney

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Park, Jee Min ; Won, Sung Chul ; Shin, Jae Il ; Yim, Hyunee ; Pai, Ki Soo. / Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria. In: Pediatric Nephrology. 2011 ; Vol. 26, No. 3. pp. 411-417.
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Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria. / Park, Jee Min; Won, Sung Chul; Shin, Jae Il; Yim, Hyunee; Pai, Ki Soo.

In: Pediatric Nephrology, Vol. 26, No. 3, 01.03.2011, p. 411-417.

Research output: Contribution to journalArticle

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