Cystatin C is better than serum creatinine for estimating glomerular filtration rate to detect osteopenia in chronic kidney disease patients

Young Eun Kwon, Mi Jung Lee, Kyoung Sook Park, Seung Hyeok Han, Tae Hyun Yoo, Kook Hwan Oh, Joongyub Lee, Kyu Beck Lee, Wookyung Chung, Yeong Hoon Kim, Curie Ahn, Kyu Hun Choi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Purpose: Recent studies have reported that loss of bone mass is associated with renal function decline and increased fracture risks in chronic kidney disease (CKD) patients. The aim of this study was to investigate the best estimated glomerular filtration rate (eGFR) equation to detect osteopenia in CKD patients. Materials and Methods: This was a cross-sectional study, and 780 patients aged 50 years or above were classified into normal bone mass or osteopenia groups according to the -1.0 of T-scores at total hip and femur neck. Comparisons of area under the receiver operating characteristic (ROC) curves (AUC) were performed to investigate significant differences among three eGFR formulas: Modification of Diet in Renal Disease, CKD-Epidemiology Collaboration (EPI) creatinine, and CKD-EPI cystatin C (CKD-EPICys). Results: The mean age was 61 years old and the proportion of females was 37.3%. The total hip osteopenia group showed lower CKD-EPI-Cys eGFR levels (osteopenia group, 33.3±19.0 mL/min/1.73 m2; normal group, 48.1±26.2 mL/min/1.73 m2, p<0.001). In multiple logistic regression analysis, CKD-EPI-Cys eGFR was independently associated with osteopenia at the total hip (per 1 mL/min/1.73 m2 increase, odds ratio 0.98, 95% confidence interval 0.97–0.99, p=0.004) after adjusting for confounding variables. ROC curve analyses indicated that CKD-EPI-Cys shows the largest AUC for osteopenia at the total hip (AUC=0.678, all p<0.01) and the femur neck (AUC=0.665, all p<0.05). Conclusion: Decreased renal function assessed by CKD-EPI-Cys equation correlates with osteopenia better than creatininebased methods in CKD patients, and the CKD-EPI-Cys formula might be a useful tool to assess skeletal-related event risks.

Original languageEnglish
Pages (from-to)380-387
Number of pages8
JournalYonsei medical journal
Issue number2
Publication statusPublished - 2017 Mar

Bibliographical note

Funding Information:
This work was supported by the Research Program funded by the Korea Centers for Disease Control and Prevention (2011E3300300, 2012E3301100, 2013E3301600).

Publisher Copyright:
© Yonsei University College of Medicine 2017.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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