Cytochrome c biogenesis: The Ccm system

Carsten Sanders, Serdar Turkarslan, Dong Woo Lee, Fevzi Daldal

Research output: Contribution to journalReview article

93 Citations (Scopus)

Abstract

Cytochromes of c-type contain covalently attached hemes that are formed via thioether bonds between the vinyls of heme b and cysteines within C1XXC2H motifs of apocytochromes. In diverse organisms this post-translational modification relies on membraneassociated specific biogenesis proteins, referred to as cytochrome c maturation (Ccm) systems. A highly complex version of these systems, Ccm or System I, is found in Gram-negative bacteria, archaea and plant mitochondria. We describe emerging functional interactions between the Ccm components categorized into three conserved modules, and present a mechanistic view of the molecular basis of ubiquitous vinyl-2~ys1 and vinyl-4~ys2 heme b-apocytochrome thioether bonds in c-type cytochromes.

Original languageEnglish
Pages (from-to)266-274
Number of pages9
JournalTrends in Microbiology
Volume18
Issue number6
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Cytochromes c
Heme
Cytochrome c Group
Sulfides
Archaea
Post Translational Protein Processing
Gram-Negative Bacteria
Cysteine
Mitochondria
Proteins

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Sanders, Carsten ; Turkarslan, Serdar ; Lee, Dong Woo ; Daldal, Fevzi. / Cytochrome c biogenesis : The Ccm system. In: Trends in Microbiology. 2010 ; Vol. 18, No. 6. pp. 266-274.
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Sanders, C, Turkarslan, S, Lee, DW & Daldal, F 2010, 'Cytochrome c biogenesis: The Ccm system', Trends in Microbiology, vol. 18, no. 6, pp. 266-274. https://doi.org/10.1016/j.tim.2010.03.006

Cytochrome c biogenesis : The Ccm system. / Sanders, Carsten; Turkarslan, Serdar; Lee, Dong Woo; Daldal, Fevzi.

In: Trends in Microbiology, Vol. 18, No. 6, 01.01.2010, p. 266-274.

Research output: Contribution to journalReview article

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