Cytogenetics and prognosis for uveal melanoma in Korean patients

Christopher Seungkyu Lee, Junwon Lee, Jun Jeong Choi, Woo Ik Yang, Jin Sook Yoon, Sang Yeul Lee, Sung Chul Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To determine the rate of mortality for uveal melanoma in the Korean population and assess whether it correlates with cytogenetic data, and clinical and histopathological factors. Methods: A retrospective review of medical files from 33 uveal melanoma patients who underwent enucleation at Yonsei University, Seoul, Korea, between January, 1994 and December, 2009 was performed. Dual-colour fluorescence in situ hybridization was performed using centromeric probes for chromosome 3 and 8 in archived patient tissues. Results: The mean age of patients was 53.2 years (range; 29-78), and the mean largest basal diameter was 11.8 mm (range; 6.0-18.1). Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate ≥5/40 high-power fields (p = 0.006), closed extravascular matrix loop (p = 0.025), large basal tumour diameter (p = 0.029) and epithelioid cellularity (p = 0.038) predicted melanoma-related mortality. The median time from enucleation to liver metastasis was 16 months (range; 10-70), and the median survival after metastasis was 5 months (range; 1-9). The Kaplan-Meier survival curve estimated the metastatic death rate to be 22% for 5 years and 30% for 10 years. Conclusions: Korean patients with uveal melanoma are younger and appear to exhibit no worse prognosis than Caucasian. Cytogenetic abnormality of chromosome 3 and 8 highly predicted metastatic death.

Original languageEnglish
Pages (from-to)e310-e314
JournalActa Ophthalmologica
Volume89
Issue number4
DOIs
Publication statusPublished - 2011 Jun 1

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Cytogenetics
Monosomy
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 3
Mortality
Neoplasm Metastasis
Ciliary Body
Kaplan-Meier Estimate
Korea
Fluorescence In Situ Hybridization
Chromosome Aberrations
Melanoma
Color
Survival
Uveal melanoma
Liver
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Lee, Christopher Seungkyu ; Lee, Junwon ; Choi, Jun Jeong ; Yang, Woo Ik ; Yoon, Jin Sook ; Lee, Sang Yeul ; Lee, Sung Chul. / Cytogenetics and prognosis for uveal melanoma in Korean patients. In: Acta Ophthalmologica. 2011 ; Vol. 89, No. 4. pp. e310-e314.
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abstract = "Purpose: To determine the rate of mortality for uveal melanoma in the Korean population and assess whether it correlates with cytogenetic data, and clinical and histopathological factors. Methods: A retrospective review of medical files from 33 uveal melanoma patients who underwent enucleation at Yonsei University, Seoul, Korea, between January, 1994 and December, 2009 was performed. Dual-colour fluorescence in situ hybridization was performed using centromeric probes for chromosome 3 and 8 in archived patient tissues. Results: The mean age of patients was 53.2 years (range; 29-78), and the mean largest basal diameter was 11.8 mm (range; 6.0-18.1). Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35{\%}) and polysomy 8 in four (20{\%}). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate ≥5/40 high-power fields (p = 0.006), closed extravascular matrix loop (p = 0.025), large basal tumour diameter (p = 0.029) and epithelioid cellularity (p = 0.038) predicted melanoma-related mortality. The median time from enucleation to liver metastasis was 16 months (range; 10-70), and the median survival after metastasis was 5 months (range; 1-9). The Kaplan-Meier survival curve estimated the metastatic death rate to be 22{\%} for 5 years and 30{\%} for 10 years. Conclusions: Korean patients with uveal melanoma are younger and appear to exhibit no worse prognosis than Caucasian. Cytogenetic abnormality of chromosome 3 and 8 highly predicted metastatic death.",
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Cytogenetics and prognosis for uveal melanoma in Korean patients. / Lee, Christopher Seungkyu; Lee, Junwon; Choi, Jun Jeong; Yang, Woo Ik; Yoon, Jin Sook; Lee, Sang Yeul; Lee, Sung Chul.

In: Acta Ophthalmologica, Vol. 89, No. 4, 01.06.2011, p. e310-e314.

Research output: Contribution to journalArticle

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T1 - Cytogenetics and prognosis for uveal melanoma in Korean patients

AU - Lee, Christopher Seungkyu

AU - Lee, Junwon

AU - Choi, Jun Jeong

AU - Yang, Woo Ik

AU - Yoon, Jin Sook

AU - Lee, Sang Yeul

AU - Lee, Sung Chul

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Purpose: To determine the rate of mortality for uveal melanoma in the Korean population and assess whether it correlates with cytogenetic data, and clinical and histopathological factors. Methods: A retrospective review of medical files from 33 uveal melanoma patients who underwent enucleation at Yonsei University, Seoul, Korea, between January, 1994 and December, 2009 was performed. Dual-colour fluorescence in situ hybridization was performed using centromeric probes for chromosome 3 and 8 in archived patient tissues. Results: The mean age of patients was 53.2 years (range; 29-78), and the mean largest basal diameter was 11.8 mm (range; 6.0-18.1). Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate ≥5/40 high-power fields (p = 0.006), closed extravascular matrix loop (p = 0.025), large basal tumour diameter (p = 0.029) and epithelioid cellularity (p = 0.038) predicted melanoma-related mortality. The median time from enucleation to liver metastasis was 16 months (range; 10-70), and the median survival after metastasis was 5 months (range; 1-9). The Kaplan-Meier survival curve estimated the metastatic death rate to be 22% for 5 years and 30% for 10 years. Conclusions: Korean patients with uveal melanoma are younger and appear to exhibit no worse prognosis than Caucasian. Cytogenetic abnormality of chromosome 3 and 8 highly predicted metastatic death.

AB - Purpose: To determine the rate of mortality for uveal melanoma in the Korean population and assess whether it correlates with cytogenetic data, and clinical and histopathological factors. Methods: A retrospective review of medical files from 33 uveal melanoma patients who underwent enucleation at Yonsei University, Seoul, Korea, between January, 1994 and December, 2009 was performed. Dual-colour fluorescence in situ hybridization was performed using centromeric probes for chromosome 3 and 8 in archived patient tissues. Results: The mean age of patients was 53.2 years (range; 29-78), and the mean largest basal diameter was 11.8 mm (range; 6.0-18.1). Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate ≥5/40 high-power fields (p = 0.006), closed extravascular matrix loop (p = 0.025), large basal tumour diameter (p = 0.029) and epithelioid cellularity (p = 0.038) predicted melanoma-related mortality. The median time from enucleation to liver metastasis was 16 months (range; 10-70), and the median survival after metastasis was 5 months (range; 1-9). The Kaplan-Meier survival curve estimated the metastatic death rate to be 22% for 5 years and 30% for 10 years. Conclusions: Korean patients with uveal melanoma are younger and appear to exhibit no worse prognosis than Caucasian. Cytogenetic abnormality of chromosome 3 and 8 highly predicted metastatic death.

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