Cytologic characteristics and β-catenin immunocytochemistry on smear slide of cribriform-morular variant of papillary thyroid carcinoma

JaSeung Koo, Woohee Jung, Soon Won Hong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: The purpose of this study is to analyze the characteristic cytologic features of the cribriform-morular variant of papillary thyroid carcinoma (CVPTC) and to find out the possibility of a preoperative diagnosis of CVPTC in fine needle aspiration (FNA). Study Design: A retrospective review of cytologic features of 5 patients who were diagnosed with CVPTC after thyroidectomy and underwent preoperative FNA was performed. In addition, β-catenin immunocytochemistry on a smear slide was applied. Results: All cases showed a high cellularity smear, cribriform architecture, ovoid/columnar cells, obvious nucleoli, and nuclear groove. Epithelial morules were observed in 4 (80%) cases. All cases demonstrated a nuclear and cytoplasmic expression in β-catenin immunocytochemistry applied to a smear slide. Conclusion: Preoperative diagnosis of CVPTC can be made by cytologic features of cribriform architecture, epithelial morule, and columnar cells in FNA and β-catenin immunocytochemistry on a smear slide showing a nuclear and cytoplasm expression.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalActa Cytologica
Volume55
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this