Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: Morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma

Se Hoon Kim, Kwang Gil Lee, Tai Seung Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To evaluate the squash smear features of subependymal giant cell astrocytoma (SEGA) in comparison with gemistocytic astrocytoma and giant cell glioblastoma. Study Design: We compared the squash smear features of 3 cases of SEGA, 9 cases of gemistocytic astrocytoma and 3 cases of giant cell glioblastoma with the morphometric findings. Results: SEGA had, on average, a 15.84 ± 5.03-μm nucleus, 33.22 ± 12.05-μm cytoplasm and 0.50 ± 0.12 nuclear/cytoplasmic ratio in squash smears. In addition, SEGA showed hairlike processes distributed along the squash direction like strap cells. While the gemistocytic astrocytoma had several tumor cells showing a vertically located nucleus, the tumor cells of SEGA showed nuclei oriented mainly in parallel. Conclusion: These squash cytologic features of SEGA can be very helpful in the differential diagnosis by excluding mimics.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalActa Cytologica
Volume51
Issue number3
DOIs
Publication statusPublished - 2007 Jan 1

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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