Abstract
OBJECTIVE: To describe and compare the cytologic features of angiosarcoma (AS) and epithelioid hemangioendothelioma (EH) of the liver. STUDY DESIGN: Fine needle aspirates and succeeding tissue biopsies from one case each of hepatic AS and EH were obtained. Both aspirates were compared for differences in cytologic features. RESULTS: In the case of EH, the tumor cells were dispersed almost singly but occasionally assumed an acinuslike shape. They were polymorphic and had a folded nuclear outline withlacy and hematoxyphilic cytoplasm. Occasional intranuclear cytoplasmic inclusions and frequent binucleated or multinucleated giant cells were also characteristic. The tumor cells of AS showed tightly cohesive clusters forming syncytium in the bloody background with heavy aggregates of polymorphonuclear cells. The tumorcells were larger and more atypical but less polymorphic than those of EH. Each tumor cell of AS had a very distinct, huge, eosinophilic nucleolus and abundant cytoplasm of honeycombing micro/macrovesicular features. Frequently, huge intracytoplasmic vacuoles similar to those in signet-ring cells were present. CONCLUSION: Preoperative diagnosis of malignant hepatic vascular tumor is possible by aspiration cytology provided that one is aware of these entities and some distinctive cytologic findings.
| Original language | English |
|---|---|
| Pages (from-to) | 1468-1476 |
| Number of pages | 9 |
| Journal | Acta Cytologica |
| Volume | 41 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1997 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Histology
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Cytologic evaluation of primary malignant vascular tumors of the liver : One case each of angiosarcoma and epithelioid hemangioendotheliom. / Cho, Nam Hoon; Lee, Kwang Gil; Jeong, Mi Gyoung.
In: Acta Cytologica, Vol. 41, No. 5, 01.01.1997, p. 1468-1476.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cytologic evaluation of primary malignant vascular tumors of the liver
T2 - One case each of angiosarcoma and epithelioid hemangioendotheliom
AU - Cho, Nam Hoon
AU - Lee, Kwang Gil
AU - Jeong, Mi Gyoung
PY - 1997/1/1
Y1 - 1997/1/1
N2 - OBJECTIVE: To describe and compare the cytologic features of angiosarcoma (AS) and epithelioid hemangioendothelioma (EH) of the liver. STUDY DESIGN: Fine needle aspirates and succeeding tissue biopsies from one case each of hepatic AS and EH were obtained. Both aspirates were compared for differences in cytologic features. RESULTS: In the case of EH, the tumor cells were dispersed almost singly but occasionally assumed an acinuslike shape. They were polymorphic and had a folded nuclear outline withlacy and hematoxyphilic cytoplasm. Occasional intranuclear cytoplasmic inclusions and frequent binucleated or multinucleated giant cells were also characteristic. The tumor cells of AS showed tightly cohesive clusters forming syncytium in the bloody background with heavy aggregates of polymorphonuclear cells. The tumorcells were larger and more atypical but less polymorphic than those of EH. Each tumor cell of AS had a very distinct, huge, eosinophilic nucleolus and abundant cytoplasm of honeycombing micro/macrovesicular features. Frequently, huge intracytoplasmic vacuoles similar to those in signet-ring cells were present. CONCLUSION: Preoperative diagnosis of malignant hepatic vascular tumor is possible by aspiration cytology provided that one is aware of these entities and some distinctive cytologic findings.
AB - OBJECTIVE: To describe and compare the cytologic features of angiosarcoma (AS) and epithelioid hemangioendothelioma (EH) of the liver. STUDY DESIGN: Fine needle aspirates and succeeding tissue biopsies from one case each of hepatic AS and EH were obtained. Both aspirates were compared for differences in cytologic features. RESULTS: In the case of EH, the tumor cells were dispersed almost singly but occasionally assumed an acinuslike shape. They were polymorphic and had a folded nuclear outline withlacy and hematoxyphilic cytoplasm. Occasional intranuclear cytoplasmic inclusions and frequent binucleated or multinucleated giant cells were also characteristic. The tumor cells of AS showed tightly cohesive clusters forming syncytium in the bloody background with heavy aggregates of polymorphonuclear cells. The tumorcells were larger and more atypical but less polymorphic than those of EH. Each tumor cell of AS had a very distinct, huge, eosinophilic nucleolus and abundant cytoplasm of honeycombing micro/macrovesicular features. Frequently, huge intracytoplasmic vacuoles similar to those in signet-ring cells were present. CONCLUSION: Preoperative diagnosis of malignant hepatic vascular tumor is possible by aspiration cytology provided that one is aware of these entities and some distinctive cytologic findings.
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UR - http://www.scopus.com/inward/citedby.url?scp=1842295157&partnerID=8YFLogxK
U2 - 10.1159/000332861
DO - 10.1159/000332861
M3 - Article
VL - 41
SP - 1468
EP - 1476
JO - Acta Cytologica
JF - Acta Cytologica
SN - 0001-5547
IS - 5
ER -