Cytoplasmic HuR expression

Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells

Jeong Dan Cha, Hee Kyeong Kim, In Ho Cha

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. Methods To assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples. Results In the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6% of samples and positive cIAP2 expression was noted in 95.8% of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p <.035) and high cIAP2 expression (p <.007), as well as high grade (p <.050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells. Conclusion Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1168-1175, 2014

Original languageEnglish
Pages (from-to)1168-1175
Number of pages8
JournalHead and Neck
Volume36
Issue number8
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Inhibitor of Apoptosis Proteins
Squamous Cell Carcinoma
Mouth Neoplasms
Small Interfering RNA
Neoplasms
Carcinogenesis
Head

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Medicine(all)

Cite this

@article{056999fccfc64d50abfd8228f027470c,
title = "Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells",
abstract = "Background HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. Methods To assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples. Results In the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6{\%} of samples and positive cIAP2 expression was noted in 95.8{\%} of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p <.035) and high cIAP2 expression (p <.007), as well as high grade (p <.050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells. Conclusion Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs. {\circledC} 2014 Wiley Periodicals, Inc. Head Neck 36: 1168-1175, 2014",
author = "Cha, {Jeong Dan} and Kim, {Hee Kyeong} and Cha, {In Ho}",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/hed.23431",
language = "English",
volume = "36",
pages = "1168--1175",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

Cytoplasmic HuR expression : Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells. / Cha, Jeong Dan; Kim, Hee Kyeong; Cha, In Ho.

In: Head and Neck, Vol. 36, No. 8, 01.01.2014, p. 1168-1175.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cytoplasmic HuR expression

T2 - Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells

AU - Cha, Jeong Dan

AU - Kim, Hee Kyeong

AU - Cha, In Ho

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. Methods To assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples. Results In the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6% of samples and positive cIAP2 expression was noted in 95.8% of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p <.035) and high cIAP2 expression (p <.007), as well as high grade (p <.050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells. Conclusion Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1168-1175, 2014

AB - Background HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. Methods To assess the correlation between cIAP2 and HuR in cases of oral squamous cell carcinoma (OSCC), the expression patterns of HuR and cIAP2 were assessed by immunohistochemical analyses of 95 treated OSCC samples. Results In the tumor tissues, positive cytoplasmic HuR expression was evident in 71.6% of samples and positive cIAP2 expression was noted in 95.8% of samples. Positive cytoplasmic HuR expression was significantly associated with positive cIAP2 (p <.035) and high cIAP2 expression (p <.007), as well as high grade (p <.050). The inhibition of HuR expression by small interfering RNA or leptomycin B caused a reduction in the inducibility of cIAP2 in oral cancer cells. Conclusion Cytoplasmic expression of HuR is associated with cIAP2 expression in OSCCs. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1168-1175, 2014

UR - http://www.scopus.com/inward/record.url?scp=84904270337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904270337&partnerID=8YFLogxK

U2 - 10.1002/hed.23431

DO - 10.1002/hed.23431

M3 - Article

VL - 36

SP - 1168

EP - 1175

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 8

ER -