Cytoplasmic MYC is an anti-necroptotic protein

Eun Woo Lee; Daehyeon Seong; Jaewhan Song

doi:10.1080/23723556.2020.1817697

Cytoplasmic MYC is an anti-necroptotic protein

Eun Woo Lee, Daehyeon Seong, Jaewhan Song

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.

Original language	English
Article number	1817697
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2020.1817697
Publication status	Published - 2020 Nov 1

Bibliographical note

Funding Information:
This study was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning [NRF-2015R1A3A2066581 to J.S. and NRF-2019R1C1C1002831 to E.W.L].

Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2020.1817697

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abstract = "Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.",

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AU - Song, Jaewhan

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N2 - Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.

AB - Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.

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Cytoplasmic MYC is an anti-necroptotic protein

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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