Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.
Bibliographical noteFunding Information:
This study was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning [NRF-2015R1A3A2066581 to J.S. and NRF-2019R1C1C1002831 to E.W.L].
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Cancer Research