Cytoplasmic MYC is an anti-necroptotic protein

Eun Woo Lee, Daehyeon Seong, Jaewhan Song

Research output: Contribution to journalArticlepeer-review


Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.

Original languageEnglish
Article number1817697
JournalMolecular and Cellular Oncology
Issue number6
Publication statusPublished - 2020 Nov 1

Bibliographical note

Funding Information:
This study was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning [NRF-2015R1A3A2066581 to J.S. and NRF-2019R1C1C1002831 to E.W.L].

Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research


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