Cytoplasmic MYC is an anti-necroptotic protein

Eun Woo Lee, Daehyeon Seong, Jaewhan Song

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.

Original languageEnglish
Article number1817697
JournalMolecular and Cellular Oncology
Volume7
Issue number6
DOIs
Publication statusPublished - 2020 Nov 1

Bibliographical note

Funding Information:
This study was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning [NRF-2015R1A3A2066581 to J.S. and NRF-2019R1C1C1002831 to E.W.L].

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

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