Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines

Chung Kyu Ryu, Hye Young Kang, Yu Jin Yi, Chong Ock Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalArchives of pharmacal research
Volume23
Issue number1
DOIs
Publication statusPublished - 2000 Feb

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Cyclin-Dependent Kinases
Tumor Cell Line
Tumors
Melanoma
Colon
Cells
Lung
Cytotoxicity
Assays
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

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title = "Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines",
abstract = "6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.",
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Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines. / Ryu, Chung Kyu; Kang, Hye Young; Yi, Yu Jin; Lee, Chong Ock.

In: Archives of pharmacal research, Vol. 23, No. 1, 02.2000, p. 42-45.

Research output: Contribution to journalArticle

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AB - 6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

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