Cytotoxic sesquiterpene glucosides from Fissistigma pallens

Ngo Sy Thinh, Nguyen Thi Bich Thu, Tran Minh Ngoc, Nguyen Minh Khoi, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Nguyen Xuan Nhiem, Yohan Seo, Wan Namkung, Seon Ju Park, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC50 values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC50 value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC50 values ranging from 3.8 to 7.2 μM.

Original languageEnglish
Article number112255
Publication statusPublished - 2020 Apr

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development ( NAFOSTED ) under grant number 104.01–2015.79 and by the National Research Foundation of Korea ( NRF ) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea.

Publisher Copyright:
© 2020 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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