Cytotoxic sesquiterpene glucosides from Fissistigma pallens

Ngo Sy Thinh, Nguyen Thi Bich Thu, Tran Minh Ngoc, Nguyen Minh Khoi, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Nguyen Xuan Nhiem, Yohan Seo, Wan Namkung, Seon Ju Park, Seung Hyun Kim

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Abstract

Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC50 values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC50 value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC50 values ranging from 3.8 to 7.2 μM.

Original languageEnglish
Article number112255
JournalPhytochemistry
Volume172
DOIs
Publication statusPublished - 2020 Apr

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Cite this

Thinh, N. S., Bich Thu, N. T., Ngoc, T. M., Khoi, N. M., Tai, B. H., Van Kiem, P., Van Minh, C., Nhiem, N. X., Seo, Y., Namkung, W., Park, S. J., & Kim, S. H. (2020). Cytotoxic sesquiterpene glucosides from Fissistigma pallens. Phytochemistry, 172, [112255]. https://doi.org/10.1016/j.phytochem.2019.112255