Cytotoxic sesquiterpene glucosides from Fissistigma pallens

Ngo Sy Thinh; Nguyen Thi Bich Thu; Tran Minh Ngoc; Nguyen Minh Khoi; Bui Huu Tai; Phan Van Kiem; Chau Van Minh; Nguyen Xuan Nhiem; Yohan Seo; Wan Namkung; Seon Ju Park; Seung Hyun Kim

doi:10.1016/j.phytochem.2019.112255

Cytotoxic sesquiterpene glucosides from Fissistigma pallens

Ngo Sy Thinh, Nguyen Thi Bich Thu, Tran Minh Ngoc, Nguyen Minh Khoi, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Nguyen Xuan Nhiem, Yohan Seo, Wan Namkung, Seon Ju Park, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC₅₀ values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC₅₀ value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC₅₀ values ranging from 3.8 to 7.2 μM.

Original language	English
Article number	112255
Journal	Phytochemistry
Volume	172
DOIs	https://doi.org/10.1016/j.phytochem.2019.112255
Publication status	Published - 2020 Apr

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development ( NAFOSTED ) under grant number 104.01–2015.79 and by the National Research Foundation of Korea ( NRF ) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea.

Publisher Copyright:
© 2020 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

UN SDGs

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10.1016/j.phytochem.2019.112255

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title = "Cytotoxic sesquiterpene glucosides from Fissistigma pallens",

abstract = "Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC50 values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC50 value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC50 values ranging from 3.8 to 7.2 μM.",

author = "Thinh, {Ngo Sy} and {Bich Thu}, {Nguyen Thi} and Ngoc, {Tran Minh} and Khoi, {Nguyen Minh} and Tai, {Bui Huu} and {Van Kiem}, Phan and {Van Minh}, Chau and Nhiem, {Nguyen Xuan} and Yohan Seo and Wan Namkung and Park, {Seon Ju} and Kim, {Seung Hyun}",

note = "Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development ( NAFOSTED ) under grant number 104.01–2015.79 and by the National Research Foundation of Korea ( NRF ) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = apr,

doi = "10.1016/j.phytochem.2019.112255",

language = "English",

volume = "172",

journal = "Phytochemistry",

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T1 - Cytotoxic sesquiterpene glucosides from Fissistigma pallens

AU - Thinh, Ngo Sy

AU - Bich Thu, Nguyen Thi

AU - Ngoc, Tran Minh

AU - Khoi, Nguyen Minh

AU - Tai, Bui Huu

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Nhiem, Nguyen Xuan

AU - Seo, Yohan

AU - Namkung, Wan

AU - Park, Seon Ju

AU - Kim, Seung Hyun

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development ( NAFOSTED ) under grant number 104.01–2015.79 and by the National Research Foundation of Korea ( NRF ) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology , Republic of Korea. Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/4

Y1 - 2020/4

N2 - Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC50 values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC50 value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC50 values ranging from 3.8 to 7.2 μM.

AB - Six undescribed sesquiterpene glucosides, fissispallins A-F, and one known sesquiterpene glucoside, fissispallin, were discovered in the leaves of Fissistigma pallens (Finet & Gagnep.) Merr. The structures were determined using spectroscopic methods, including 1D, 2D NMR, and MS. All compounds were evaluated for cytotoxic activity against three human cancer cell lines, HT-29, A-2058, and A-549. Fissispallin A showed potent activity with the IC50 values less than 1.5 μM against all tested human cancer cell lines. Fissispallin also showed potent activity with IC50 value of 0.4 ± 0.3 on the A-2058 cancer cell lines. Fissispallins B-D showed significant cytotoxic activity against all the tested cancer cell lines with IC50 values ranging from 3.8 to 7.2 μM.

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Cytotoxic sesquiterpene glucosides from Fissistigma pallens

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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