Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3

Naziah M. Latiff, Carmen C. Mayorga-Martinez, Bahareh Khezri, Katerina Szokolova, Zdeněk Sofer, Adrian C. Fisher, Martin Pumera

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Metal phosphorus chalcogenides is a new class of 2D materials that have shown interesting semiconducting, electronic, anisotropic, magnetic, dielectric, structural and optical properties. Recently, NiPS3, FePS3 and CoPS3 in particular have been highlighted for promising potential in important energy applications such as electrocatalysts for water splitting and hydrogen storage. However, little is known about the toxicological hazards that they may pose on humans. Here, we investigated the cytotoxicity of NiPS3, FePS3 and CoPS3 on human lung carcinoma cells (A549) and normal human bronchial cells (BEAS-2B) to address this concern. Upon treatment of these cells with different MPXY materials, we determined the remaining cell viability using water soluble tetrazolium salt (WST-8) assay. We found that CoPS3 was most toxic followed by FePS3 with intermediate toxicity while NiPS3 showed the lowest toxicity among the three materials tested for both cell lines. When viewed with other layered materials, these MPXY samples present comparable toxicities with transition metal dichalcogenides and black phosphorus at low concentrations.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalFlatChem
Volume12
DOIs
Publication statusPublished - 2018 Nov

Fingerprint

Chalcogenides
Cytotoxicity
Phosphorus
Metals
Cells
Toxicity
Tetrazolium Salts
Water
Electrocatalysts
Poisons
Hydrogen storage
Dielectric properties
Transition metals
Structural properties
Assays
Magnetic properties
Hazards
Optical properties
Salts

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Latiff, N. M., Mayorga-Martinez, C. C., Khezri, B., Szokolova, K., Sofer, Z., Fisher, A. C., & Pumera, M. (2018). Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3 FlatChem, 12, 1-9. https://doi.org/10.1016/j.flatc.2018.11.003
Latiff, Naziah M. ; Mayorga-Martinez, Carmen C. ; Khezri, Bahareh ; Szokolova, Katerina ; Sofer, Zdeněk ; Fisher, Adrian C. ; Pumera, Martin. / Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3 In: FlatChem. 2018 ; Vol. 12. pp. 1-9.
@article{db16abd43ee147e7a85c1cee06f59ecc,
title = "Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3",
abstract = "Metal phosphorus chalcogenides is a new class of 2D materials that have shown interesting semiconducting, electronic, anisotropic, magnetic, dielectric, structural and optical properties. Recently, NiPS3, FePS3 and CoPS3 in particular have been highlighted for promising potential in important energy applications such as electrocatalysts for water splitting and hydrogen storage. However, little is known about the toxicological hazards that they may pose on humans. Here, we investigated the cytotoxicity of NiPS3, FePS3 and CoPS3 on human lung carcinoma cells (A549) and normal human bronchial cells (BEAS-2B) to address this concern. Upon treatment of these cells with different MPXY materials, we determined the remaining cell viability using water soluble tetrazolium salt (WST-8) assay. We found that CoPS3 was most toxic followed by FePS3 with intermediate toxicity while NiPS3 showed the lowest toxicity among the three materials tested for both cell lines. When viewed with other layered materials, these MPXY samples present comparable toxicities with transition metal dichalcogenides and black phosphorus at low concentrations.",
author = "Latiff, {Naziah M.} and Mayorga-Martinez, {Carmen C.} and Bahareh Khezri and Katerina Szokolova and Zdeněk Sofer and Fisher, {Adrian C.} and Martin Pumera",
year = "2018",
month = "11",
doi = "10.1016/j.flatc.2018.11.003",
language = "English",
volume = "12",
pages = "1--9",
journal = "FlatChem",
issn = "2452-2627",
publisher = "Elsevier BV",

}

Latiff, NM, Mayorga-Martinez, CC, Khezri, B, Szokolova, K, Sofer, Z, Fisher, AC & Pumera, M 2018, 'Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3 ', FlatChem, vol. 12, pp. 1-9. https://doi.org/10.1016/j.flatc.2018.11.003

Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3 . / Latiff, Naziah M.; Mayorga-Martinez, Carmen C.; Khezri, Bahareh; Szokolova, Katerina; Sofer, Zdeněk; Fisher, Adrian C.; Pumera, Martin.

In: FlatChem, Vol. 12, 11.2018, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3

AU - Latiff, Naziah M.

AU - Mayorga-Martinez, Carmen C.

AU - Khezri, Bahareh

AU - Szokolova, Katerina

AU - Sofer, Zdeněk

AU - Fisher, Adrian C.

AU - Pumera, Martin

PY - 2018/11

Y1 - 2018/11

N2 - Metal phosphorus chalcogenides is a new class of 2D materials that have shown interesting semiconducting, electronic, anisotropic, magnetic, dielectric, structural and optical properties. Recently, NiPS3, FePS3 and CoPS3 in particular have been highlighted for promising potential in important energy applications such as electrocatalysts for water splitting and hydrogen storage. However, little is known about the toxicological hazards that they may pose on humans. Here, we investigated the cytotoxicity of NiPS3, FePS3 and CoPS3 on human lung carcinoma cells (A549) and normal human bronchial cells (BEAS-2B) to address this concern. Upon treatment of these cells with different MPXY materials, we determined the remaining cell viability using water soluble tetrazolium salt (WST-8) assay. We found that CoPS3 was most toxic followed by FePS3 with intermediate toxicity while NiPS3 showed the lowest toxicity among the three materials tested for both cell lines. When viewed with other layered materials, these MPXY samples present comparable toxicities with transition metal dichalcogenides and black phosphorus at low concentrations.

AB - Metal phosphorus chalcogenides is a new class of 2D materials that have shown interesting semiconducting, electronic, anisotropic, magnetic, dielectric, structural and optical properties. Recently, NiPS3, FePS3 and CoPS3 in particular have been highlighted for promising potential in important energy applications such as electrocatalysts for water splitting and hydrogen storage. However, little is known about the toxicological hazards that they may pose on humans. Here, we investigated the cytotoxicity of NiPS3, FePS3 and CoPS3 on human lung carcinoma cells (A549) and normal human bronchial cells (BEAS-2B) to address this concern. Upon treatment of these cells with different MPXY materials, we determined the remaining cell viability using water soluble tetrazolium salt (WST-8) assay. We found that CoPS3 was most toxic followed by FePS3 with intermediate toxicity while NiPS3 showed the lowest toxicity among the three materials tested for both cell lines. When viewed with other layered materials, these MPXY samples present comparable toxicities with transition metal dichalcogenides and black phosphorus at low concentrations.

UR - http://www.scopus.com/inward/record.url?scp=85057529162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057529162&partnerID=8YFLogxK

U2 - 10.1016/j.flatc.2018.11.003

DO - 10.1016/j.flatc.2018.11.003

M3 - Article

AN - SCOPUS:85057529162

VL - 12

SP - 1

EP - 9

JO - FlatChem

JF - FlatChem

SN - 2452-2627

ER -

Latiff NM, Mayorga-Martinez CC, Khezri B, Szokolova K, Sofer Z, Fisher AC et al. Cytotoxicity of layered metal phosphorus chalcogenides (MPXY) nanoflakes; FePS3, CoPS3, NiPS3 FlatChem. 2018 Nov;12:1-9. https://doi.org/10.1016/j.flatc.2018.11.003