Cytotoxicity of nano-materials on human bronchial epithelial cell

D. C. Shin, J. Y. Jang, J. Y. Yang, S. H. Kim, I. H. Choi, Y. W. Lim, C. S. Kim, G. T. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure. [4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells (BEAS-2B) after exposure to nano-materials (Ag and CNT). BEAS-2B cell viability decreased with decreasing doses of Ag (diameters : 40-70 and 100 nm) and MWCNT (diameters : 4-6 and 10-15 nm) nano-materials. At the higher exposure (≥200 ug/ml), all materials induced significant cell damage. Nano Ag materials increased apoptosis and cytokine expression (IL-6 and IL-8) when over 100 ug/ml concentration. All MWCNTs weakly increased apoptosis and did not significantly increased cytokine expression. In conclusion, we suggest that Ag and MWCNT nanomaterials induce variable extents of cellular toxicity in a dose-dependent and size-dependent.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages142-145
Number of pages4
Publication statusPublished - 2008 Oct 1
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: 2008 Jun 12008 Jun 5

Publication series

NameTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume2

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period08/6/108/6/5

Fingerprint

Cytotoxicity
Cell death
Cells
Nanostructured materials
Toxicity
Epithelial Cells
Cytokines

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

Cite this

Shin, D. C., Jang, J. Y., Yang, J. Y., Kim, S. H., Choi, I. H., Lim, Y. W., ... Lee, G. T. (2008). Cytotoxicity of nano-materials on human bronchial epithelial cell. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (pp. 142-145). (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).
Shin, D. C. ; Jang, J. Y. ; Yang, J. Y. ; Kim, S. H. ; Choi, I. H. ; Lim, Y. W. ; Kim, C. S. ; Lee, G. T. / Cytotoxicity of nano-materials on human bronchial epithelial cell. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. pp. 142-145 (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008).
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abstract = "This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure. [4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells (BEAS-2B) after exposure to nano-materials (Ag and CNT). BEAS-2B cell viability decreased with decreasing doses of Ag (diameters : 40-70 and 100 nm) and MWCNT (diameters : 4-6 and 10-15 nm) nano-materials. At the higher exposure (≥200 ug/ml), all materials induced significant cell damage. Nano Ag materials increased apoptosis and cytokine expression (IL-6 and IL-8) when over 100 ug/ml concentration. All MWCNTs weakly increased apoptosis and did not significantly increased cytokine expression. In conclusion, we suggest that Ag and MWCNT nanomaterials induce variable extents of cellular toxicity in a dose-dependent and size-dependent.",
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Shin, DC, Jang, JY, Yang, JY, Kim, SH, Choi, IH, Lim, YW, Kim, CS & Lee, GT 2008, Cytotoxicity of nano-materials on human bronchial epithelial cell. in Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, vol. 2, pp. 142-145, 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008, Quebec City, QC, United States, 08/6/1.

Cytotoxicity of nano-materials on human bronchial epithelial cell. / Shin, D. C.; Jang, J. Y.; Yang, J. Y.; Kim, S. H.; Choi, I. H.; Lim, Y. W.; Kim, C. S.; Lee, G. T.

Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. p. 142-145 (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Shin DC, Jang JY, Yang JY, Kim SH, Choi IH, Lim YW et al. Cytotoxicity of nano-materials on human bronchial epithelial cell. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. p. 142-145. (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008).