Cytotoxicity of Shear Exfoliated Pnictogen (As, Sb, Bi) Nanosheets

Hui Ling Chia, Naziah Mohamad Latiff, Rui Gusmão, Zdeněk Sofer, Martin Pumera

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The experimental achievement of phosphorene, which exhibits superior electronic, physical, and optical properties has spurred recent interest in other Group 15 elemental 2D nanomaterials such as arsenene, antimonene, and bismuthene. These unique and superior properties of the pnictogen nanosheets have spurred intensive research efforts and led to the discovery of their diversified potential applications; for instance, optical Kerr material, photonic devices, pnictogen-decorated microfibers, high-speed transistors, and flexible 2D electronics. Previous studies have mainly been dedicated to study the synthesis, properties, and applications of the heavy pnictogens nanosheets; however, the toxicological behaviour of these nanosheets has yet to be established. Herein, the cytotoxicity study of pnictogen nanosheets (As, Sb, and Bi) was conducted over 24 h of incubation with various concentrations of test materials and adenocarcinoma human lung epithelial A549 cells. After the treatment period, the remaining cell viabilities were obtained through absorbance measurements with WST-8 and MTT assays. These findings demonstrate that the toxicity of pnictogen nanosheets decreases down Group 15, whereby arsenic nanosheets are considered to be the most toxic, whereas bismuth nanosheets induce low cytotoxicity. The findings of this study constitute an important initial step towards enhancing our understanding of the toxicological effects of pnictogen nanosheets in light of their prospective commercial applications.

Original languageEnglish
Pages (from-to)2242-2249
Number of pages8
JournalChemistry - A European Journal
Issue number9
Publication statusPublished - 2019 Feb 11

Bibliographical note

Funding Information:
N.M.L. acknowledges that this research is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its CREATE programme. R.G. acknowledges the European Structural and Investment Funds, CHEMFELL4UCTP (No. CZ.02.2.69/0.0/0.0/17_050/0008485). This work was supported by the project Advanced Functional Nanorobots (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). Z.S. was supported by Czech Science Foundation (GACR No. 17-11456S). This work was created with the financial support of the Neuron Foundation for science support.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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