D-dimer predicts poor hospitalisation outcomes in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis

J. Y. Pyo, B. Yoo, M. Kwon, W. H. Bae, S. J. Byun, S. W. Lee, Y. B. Park, J. J. Song

Research output: Contribution to journalArticlepeer-review


Objective. The in-hospital mortality rate among patients with antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is high. Unfortunately, there is no reliable prognostic biomarker. This study aimed to investigate whether elevated D-dimer levels can predict hospitalisation outcomes among patients with AAV. Methods. We performed a retrospective analysis at a tertiary medical centre in Seoul, South Korea, between 2005 and 2019. Patients with AAV requiring hospitalisation, whose D-dimer levels were available within one week of hospitalisation, were included; patients with known alternative reasons for elevated D-dimer were excluded. Death and intensive care unit requirements were defined as adverse outcomes. Results. In total, 61 AAV patients with a total of 100 episodes of hospitalisation were included. Median D-dimer levels were significantly higher in patients with adverse outcomes than in those without adverse outcomes (1.84 vs. 0.42 mg/dL; p=0.006). Consistently, the incidence of the adverse outcomes was significantly higher in the high D-dimer group (≥0.699 mg/dL; n = 40) than in the low D-dimer group (<0.699 mg/dL; n = 60) (35% vs. 10%; p=0.002). Multivariate logistic regression analysis revealed that a high D-dimer level was a significant risk factor for adverse outcomes (hazard ratio, 4.852; 95% confidence interval, 1.320-17.833; p=0.017). Kaplan-Meier survival analysis revealed that the high D-dimer group was associated with more 30-day in-hospital adverse outcomes than the low D-dimer group (p=0.008). Conclusion. High D-dimer levels on admission are significantly associated with adverse outcomes among patients with AAV.

Original languageEnglish
Pages (from-to)S94-S100
JournalClinical and experimental rheumatology
Issue number2
Publication statusPublished - 2021

Bibliographical note

Funding Information:
Funding: this work was supported by the Basic Science Research Program (2018R1D1A1B07045202) through the National Research Foundation of Korea, and funded by the Ministry of Education, Science, and Technology. Competing interests: none declared.

Publisher Copyright:
© Copyright CliniCal and ExpErimEntal rhEumatology 2021.

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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