Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng

Jun Li Yang, Thi Kim Quy Ha, Basanta Dhodary, Kuk Hwa Kim, Junsoo Park, Chul Ho Lee, Young Choong Kim, Won Keun Oh

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22 Citations (Scopus)

Abstract

During a search for SIRT1 activators originating in nature, three new dammarane triterpenes, 6α,20(S)-dihydroxydammar-3,12-dione-24-ene (1), 6α,20(S),24(S)-trihydroxydammar-3,12-dione-25-ene (2), and 6α,20(S),25-trihydroxydammar-3,12-dione-23-ene (3), as well as two known triterpenes, dammar-20(22),24-diene-3β,6α,12β-triol (4) and 20(S)-ginsenoside Rg3 (5), were isolated from Panax ginseng leaves. Compounds 1 and 3-5 showed potential as SIRT1 activators, as analyzed by in vitro enzyme-based SIRT1-NAD/NADH and SIRT1-p53 luciferase cell-based assays. They were also found to increase the level of NAD+/NADH ratio in HEK293 cells. This study presents a new class of chemical entities that may be able to be developed as SIRT1 activators for antiaging and treatment of age-associated diseases.

Original languageEnglish
Pages (from-to)1615-1623
Number of pages9
JournalJournal of Natural Products
Volume77
Issue number7
DOIs
Publication statusPublished - 2014 Jul 25

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Yang, J. L., Ha, T. K. Q., Dhodary, B., Kim, K. H., Park, J., Lee, C. H., Kim, Y. C., & Oh, W. K. (2014). Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng. Journal of Natural Products, 77(7), 1615-1623. https://doi.org/10.1021/np5002303