De novo bone formation underneath the sinus membrane supported by a bone patch

a pilot experiment in rabbit sinus model

So Ra Yoon, Jae Kook Cha, Hyun Chang Lim, Jung Seok Lee, Seongho Choi, Ui-Won Jung

Research output: Contribution to journalArticle

Abstract

Aims: The objectives of this study were to evaluate bone regeneration beneath a newly devised bone substitute combined with collagen membrane (called a bone patch) lying over a concomitantly placed mini-implant following sinus floor elevation and verify its usefulness as a carrier system for recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbits. Materials and methods: The sinus floor elevation procedure was performed bilaterally in five rabbits. Either a plain bone patch (control group) or an rhBMP-2-loaded patch (experimental group) was randomly placed beneath the elevated sinus membrane (SM) of both sinuses, where the mini-implants were concomitantly placed. Micro-computed tomographic and histologic analyses were performed at 4 weeks post-surgery. Results: In micro-computed tomography, the median values of the total augmented volume and the mineralized bone volume were significantly higher in the experimental group than in the control group (161 vs. 122 mm3 [P < 0.01] and 48 vs. 42 mm3 [P < 0.05], respectively). Histometric analysis revealed the same outcomes, with new bone areas of 6.41 and 2.97 mm2 in the experimental and control groups, respectively (P < 0.001), and bone-to-implant contact ratios of 22.6% and 5.2%, respectively (P < 0.001). Conclusion: The newly devised bone patch in this study can support the elevated SM and facilitate bone regeneration from the basal bone with a reduced amount of biomaterial. The addition of rhBMP-2 may shorten the healing time for multidirectional bone regeneration toward the implant.

Original languageEnglish
Pages (from-to)1175-1181
Number of pages7
JournalClinical Oral Implants Research
Volume28
Issue number10
DOIs
Publication statusPublished - 2017 Oct 1

Fingerprint

Osteogenesis
Rabbits
Bone and Bones
Membranes
Bone Regeneration
Control Groups
Bone Substitutes
Biocompatible Materials
Collagen
Tomography
recombinant human bone morphogenetic protein-2

All Science Journal Classification (ASJC) codes

  • Oral Surgery

Cite this

@article{7a16b413f1f243af8bac5c06a7ff85f0,
title = "De novo bone formation underneath the sinus membrane supported by a bone patch: a pilot experiment in rabbit sinus model",
abstract = "Aims: The objectives of this study were to evaluate bone regeneration beneath a newly devised bone substitute combined with collagen membrane (called a bone patch) lying over a concomitantly placed mini-implant following sinus floor elevation and verify its usefulness as a carrier system for recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbits. Materials and methods: The sinus floor elevation procedure was performed bilaterally in five rabbits. Either a plain bone patch (control group) or an rhBMP-2-loaded patch (experimental group) was randomly placed beneath the elevated sinus membrane (SM) of both sinuses, where the mini-implants were concomitantly placed. Micro-computed tomographic and histologic analyses were performed at 4 weeks post-surgery. Results: In micro-computed tomography, the median values of the total augmented volume and the mineralized bone volume were significantly higher in the experimental group than in the control group (161 vs. 122 mm3 [P < 0.01] and 48 vs. 42 mm3 [P < 0.05], respectively). Histometric analysis revealed the same outcomes, with new bone areas of 6.41 and 2.97 mm2 in the experimental and control groups, respectively (P < 0.001), and bone-to-implant contact ratios of 22.6{\%} and 5.2{\%}, respectively (P < 0.001). Conclusion: The newly devised bone patch in this study can support the elevated SM and facilitate bone regeneration from the basal bone with a reduced amount of biomaterial. The addition of rhBMP-2 may shorten the healing time for multidirectional bone regeneration toward the implant.",
author = "Yoon, {So Ra} and Cha, {Jae Kook} and Lim, {Hyun Chang} and Lee, {Jung Seok} and Seongho Choi and Ui-Won Jung",
year = "2017",
month = "10",
day = "1",
doi = "10.1111/clr.12935",
language = "English",
volume = "28",
pages = "1175--1181",
journal = "Clinical Oral Implants Research",
issn = "0905-7161",
publisher = "Blackwell Munksgaard",
number = "10",

}

De novo bone formation underneath the sinus membrane supported by a bone patch : a pilot experiment in rabbit sinus model. / Yoon, So Ra; Cha, Jae Kook; Lim, Hyun Chang; Lee, Jung Seok; Choi, Seongho; Jung, Ui-Won.

In: Clinical Oral Implants Research, Vol. 28, No. 10, 01.10.2017, p. 1175-1181.

Research output: Contribution to journalArticle

TY - JOUR

T1 - De novo bone formation underneath the sinus membrane supported by a bone patch

T2 - a pilot experiment in rabbit sinus model

AU - Yoon, So Ra

AU - Cha, Jae Kook

AU - Lim, Hyun Chang

AU - Lee, Jung Seok

AU - Choi, Seongho

AU - Jung, Ui-Won

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Aims: The objectives of this study were to evaluate bone regeneration beneath a newly devised bone substitute combined with collagen membrane (called a bone patch) lying over a concomitantly placed mini-implant following sinus floor elevation and verify its usefulness as a carrier system for recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbits. Materials and methods: The sinus floor elevation procedure was performed bilaterally in five rabbits. Either a plain bone patch (control group) or an rhBMP-2-loaded patch (experimental group) was randomly placed beneath the elevated sinus membrane (SM) of both sinuses, where the mini-implants were concomitantly placed. Micro-computed tomographic and histologic analyses were performed at 4 weeks post-surgery. Results: In micro-computed tomography, the median values of the total augmented volume and the mineralized bone volume were significantly higher in the experimental group than in the control group (161 vs. 122 mm3 [P < 0.01] and 48 vs. 42 mm3 [P < 0.05], respectively). Histometric analysis revealed the same outcomes, with new bone areas of 6.41 and 2.97 mm2 in the experimental and control groups, respectively (P < 0.001), and bone-to-implant contact ratios of 22.6% and 5.2%, respectively (P < 0.001). Conclusion: The newly devised bone patch in this study can support the elevated SM and facilitate bone regeneration from the basal bone with a reduced amount of biomaterial. The addition of rhBMP-2 may shorten the healing time for multidirectional bone regeneration toward the implant.

AB - Aims: The objectives of this study were to evaluate bone regeneration beneath a newly devised bone substitute combined with collagen membrane (called a bone patch) lying over a concomitantly placed mini-implant following sinus floor elevation and verify its usefulness as a carrier system for recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbits. Materials and methods: The sinus floor elevation procedure was performed bilaterally in five rabbits. Either a plain bone patch (control group) or an rhBMP-2-loaded patch (experimental group) was randomly placed beneath the elevated sinus membrane (SM) of both sinuses, where the mini-implants were concomitantly placed. Micro-computed tomographic and histologic analyses were performed at 4 weeks post-surgery. Results: In micro-computed tomography, the median values of the total augmented volume and the mineralized bone volume were significantly higher in the experimental group than in the control group (161 vs. 122 mm3 [P < 0.01] and 48 vs. 42 mm3 [P < 0.05], respectively). Histometric analysis revealed the same outcomes, with new bone areas of 6.41 and 2.97 mm2 in the experimental and control groups, respectively (P < 0.001), and bone-to-implant contact ratios of 22.6% and 5.2%, respectively (P < 0.001). Conclusion: The newly devised bone patch in this study can support the elevated SM and facilitate bone regeneration from the basal bone with a reduced amount of biomaterial. The addition of rhBMP-2 may shorten the healing time for multidirectional bone regeneration toward the implant.

UR - http://www.scopus.com/inward/record.url?scp=84979671216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979671216&partnerID=8YFLogxK

U2 - 10.1111/clr.12935

DO - 10.1111/clr.12935

M3 - Article

VL - 28

SP - 1175

EP - 1181

JO - Clinical Oral Implants Research

JF - Clinical Oral Implants Research

SN - 0905-7161

IS - 10

ER -