TY - JOUR
T1 - De novo formation of basal bodies during cellular differentiation of Naegleria gruberi
T2 - Progress and hypotheses
AU - Lee, Joo Hun
PY - 2010/4
Y1 - 2010/4
N2 - Under defined laboratory conditions, Naegleria gruberi undergo an amoeba-to-flagellate differentiation. During this differentiation, N. gruberi changes its shape from an amorphous amoeba to a regular shaped flagellate and forms de novo a flagellar apparatus, which is composed of two basal bodies, two flagella, a flagellar rootlet, and cytoplasmic microtubules. The entire process is accomplished within 2 h after initiation of differentiation and more than 95% of cells in the population undergo this differentiation. This rapid and synchronous differentiation of N. gruberi provides us with a unique system in which we can study the process of de novo basal body assembly. In this review, I summarize recent findings associated with de novo basal body assembly and propose a hypothesis to explain how N. gruberi assemble two basal bodies per cell, which is what happens in the majority of cells.
AB - Under defined laboratory conditions, Naegleria gruberi undergo an amoeba-to-flagellate differentiation. During this differentiation, N. gruberi changes its shape from an amorphous amoeba to a regular shaped flagellate and forms de novo a flagellar apparatus, which is composed of two basal bodies, two flagella, a flagellar rootlet, and cytoplasmic microtubules. The entire process is accomplished within 2 h after initiation of differentiation and more than 95% of cells in the population undergo this differentiation. This rapid and synchronous differentiation of N. gruberi provides us with a unique system in which we can study the process of de novo basal body assembly. In this review, I summarize recent findings associated with de novo basal body assembly and propose a hypothesis to explain how N. gruberi assemble two basal bodies per cell, which is what happens in the majority of cells.
UR - http://www.scopus.com/inward/record.url?scp=77049120500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77049120500&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2009.12.009
DO - 10.1016/j.semcdb.2009.12.009
M3 - Review article
C2 - 20035893
AN - SCOPUS:77049120500
VL - 21
SP - 156
EP - 162
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
IS - 2
ER -