Decidualization of intranodal endometriosis in a postmenopausal woman

Hyunsoo Kim, Gun Yoon, Byoung Gie Kim, Sang Yong Song

Research output: Contribution to journalArticle

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Abstract

Here we describe an unusual case of decidualized endometriosis detected in pelvic lymph nodes. The presence of intranodal ectopic decidua in pregnant women has been described. A few cases of decidualization of endometriotic foci in the pelvic or para-aortic lymph nodes have also been associated with pregnancy. However, decidualized intranodal endometriosis occurring in a postmenopausal woman has not been described. A 52-year-old woman presented with a very large adnexal mass. Menopause occurred at the age of 47, and she had been treated with hormone replacement therapy. She received a total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic and para-aortic lymphadenectomy for clear cell carcinoma of the right ovary. Histological examination revealed the presence of ectopic decidua in several pelvic lymph nodes. The deciduas consisted of sheets of loosely cohesive, large, uniform, round cells with abundant eosinophilic cytoplasm. Typical of decidualization of intranodal endometriosis, a few irregularly shaped, inactive endometrial glands lined by single layers of columnar to cuboidal epithelium were present within the decidua. An immunohistochemical study revealed that the decidual cells were positive for CD10, vimentin, estrogen receptor and progesterone receptor, which indicated that progestin-induced decidualization had occurred in the intranodal endometriotic stroma. To the best of our knowledge, this case represents the first report of decidualized intranodal endometriosis occurring in association with hormone replacement therapy in a postmenopausal woman. Misdiagnosis of this condition as a metastatic tumor can be avoided by an awareness of these benign inclusions, supported by immunohistochemical staining results.

Original languageEnglish
Pages (from-to)1025-1030
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Volume8
Issue number1
Publication statusPublished - 2015 Jan 1

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Endometriosis
Decidua
Lymph Nodes
Hormone Replacement Therapy
Ovariectomy
Vimentin
Progestins
Progesterone Receptors
Menopause
Lymph Node Excision
Diagnostic Errors
Hysterectomy
Estrogen Receptors
Pregnant Women
Ovary
Cytoplasm
Epithelium
Staining and Labeling
Carcinoma
Pregnancy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Kim, Hyunsoo ; Yoon, Gun ; Kim, Byoung Gie ; Song, Sang Yong. / Decidualization of intranodal endometriosis in a postmenopausal woman. In: International Journal of Clinical and Experimental Pathology. 2015 ; Vol. 8, No. 1. pp. 1025-1030.
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Decidualization of intranodal endometriosis in a postmenopausal woman. / Kim, Hyunsoo; Yoon, Gun; Kim, Byoung Gie; Song, Sang Yong.

In: International Journal of Clinical and Experimental Pathology, Vol. 8, No. 1, 01.01.2015, p. 1025-1030.

Research output: Contribution to journalArticle

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