Deciphering the model pathogenic fungus Cryptococcus neoformans

Alexander Idnurm, Yong-Sun Bahn, Kirsten Nielsen, Xiaorong Lin, James A. Fraser, Joseph Heitman

Research output: Contribution to journalReview article

208 Citations (Scopus)

Abstract

Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.

Original languageEnglish
Pages (from-to)753-764
Number of pages12
JournalNature Reviews Microbiology
Volume3
Issue number10
DOIs
Publication statusPublished - 2005 Oct 1

Fingerprint

Cryptococcus neoformans
Fungi
Genome
Cryptococcus
Aspergillus nidulans
Basidiomycota
Neurospora crassa
Candida albicans
Reproduction
Virulence
Saccharomyces cerevisiae
Phenotype

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Idnurm, Alexander ; Bahn, Yong-Sun ; Nielsen, Kirsten ; Lin, Xiaorong ; Fraser, James A. ; Heitman, Joseph. / Deciphering the model pathogenic fungus Cryptococcus neoformans. In: Nature Reviews Microbiology. 2005 ; Vol. 3, No. 10. pp. 753-764.
@article{9a46f38bdefe4ed6a98cac211f117414,
title = "Deciphering the model pathogenic fungus Cryptococcus neoformans",
abstract = "Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.",
author = "Alexander Idnurm and Yong-Sun Bahn and Kirsten Nielsen and Xiaorong Lin and Fraser, {James A.} and Joseph Heitman",
year = "2005",
month = "10",
day = "1",
doi = "10.1038/nrmicro1245",
language = "English",
volume = "3",
pages = "753--764",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "10",

}

Idnurm, A, Bahn, Y-S, Nielsen, K, Lin, X, Fraser, JA & Heitman, J 2005, 'Deciphering the model pathogenic fungus Cryptococcus neoformans', Nature Reviews Microbiology, vol. 3, no. 10, pp. 753-764. https://doi.org/10.1038/nrmicro1245

Deciphering the model pathogenic fungus Cryptococcus neoformans. / Idnurm, Alexander; Bahn, Yong-Sun; Nielsen, Kirsten; Lin, Xiaorong; Fraser, James A.; Heitman, Joseph.

In: Nature Reviews Microbiology, Vol. 3, No. 10, 01.10.2005, p. 753-764.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Deciphering the model pathogenic fungus Cryptococcus neoformans

AU - Idnurm, Alexander

AU - Bahn, Yong-Sun

AU - Nielsen, Kirsten

AU - Lin, Xiaorong

AU - Fraser, James A.

AU - Heitman, Joseph

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.

AB - Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.

UR - http://www.scopus.com/inward/record.url?scp=27244439061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27244439061&partnerID=8YFLogxK

U2 - 10.1038/nrmicro1245

DO - 10.1038/nrmicro1245

M3 - Review article

VL - 3

SP - 753

EP - 764

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 10

ER -