Decrease in plasma adiponectin concentrations in patients with vasospastic angina

Soon Jun Hong, Chang Gyu Park, Hong Seog Seo, Seung Woon Rha, Jin Won Kim, Dong Joo Oh, Jung Ah Kwon, Kap No Lee, Yang Soo Jang, Young Moo Ro

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalKorean Circulation Journal
Volume36
Issue number4
DOIs
Publication statusPublished - 2006 Apr

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Adiponectin
Angina Pectoris
Odds Ratio
Confidence Intervals
Acute Coronary Syndrome
Coronary Vessels
Stable Angina
Unstable Angina
Coronary Angiography
Chest Pain
Acetylcholine
Insulin Resistance
Coronary Artery Disease
Atherosclerosis
Multivariate Analysis
Smoking
Macrophages
Myocardial Infarction
Lipids

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Hong, S. J., Park, C. G., Seo, H. S., Rha, S. W., Kim, J. W., Oh, D. J., ... Ro, Y. M. (2006). Decrease in plasma adiponectin concentrations in patients with vasospastic angina. Korean Circulation Journal, 36(4), 255-260. https://doi.org/10.4070/kcj.2006.36.4.255
Hong, Soon Jun ; Park, Chang Gyu ; Seo, Hong Seog ; Rha, Seung Woon ; Kim, Jin Won ; Oh, Dong Joo ; Kwon, Jung Ah ; Lee, Kap No ; Jang, Yang Soo ; Ro, Young Moo. / Decrease in plasma adiponectin concentrations in patients with vasospastic angina. In: Korean Circulation Journal. 2006 ; Vol. 36, No. 4. pp. 255-260.
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title = "Decrease in plasma adiponectin concentrations in patients with vasospastic angina",
abstract = "Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95{\%} confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95{\%} CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95{\%} CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.",
author = "Hong, {Soon Jun} and Park, {Chang Gyu} and Seo, {Hong Seog} and Rha, {Seung Woon} and Kim, {Jin Won} and Oh, {Dong Joo} and Kwon, {Jung Ah} and Lee, {Kap No} and Jang, {Yang Soo} and Ro, {Young Moo}",
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Hong, SJ, Park, CG, Seo, HS, Rha, SW, Kim, JW, Oh, DJ, Kwon, JA, Lee, KN, Jang, YS & Ro, YM 2006, 'Decrease in plasma adiponectin concentrations in patients with vasospastic angina', Korean Circulation Journal, vol. 36, no. 4, pp. 255-260. https://doi.org/10.4070/kcj.2006.36.4.255

Decrease in plasma adiponectin concentrations in patients with vasospastic angina. / Hong, Soon Jun; Park, Chang Gyu; Seo, Hong Seog; Rha, Seung Woon; Kim, Jin Won; Oh, Dong Joo; Kwon, Jung Ah; Lee, Kap No; Jang, Yang Soo; Ro, Young Moo.

In: Korean Circulation Journal, Vol. 36, No. 4, 04.2006, p. 255-260.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decrease in plasma adiponectin concentrations in patients with vasospastic angina

AU - Hong, Soon Jun

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Rha, Seung Woon

AU - Kim, Jin Won

AU - Oh, Dong Joo

AU - Kwon, Jung Ah

AU - Lee, Kap No

AU - Jang, Yang Soo

AU - Ro, Young Moo

PY - 2006/4

Y1 - 2006/4

N2 - Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

AB - Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

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