Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with iga nephropathy

Seung Jun Kim, Hyang Mo Koo, Beom Jin Lim, Hyung Jung Oh, Dong Eun Yoo, Dong Ho Shin, Mi Jung Lee, Fa Mee Doh, Jung Tak Park, Tae Hyun Yoo, Shin Wook Kang, Kyu Hun Choi, Hyeon Joo Jeong, Seung Hyeok Han

Research output: Contribution to journalArticle

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Abstract

Background and Aims: Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN. Methods: A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr). Results: Of the patients, there were 66 patients (19.2%) with hypoC3. During a mean follow-up of 53.7 months, ESRD occurred in 5 patients (7.6%) with hypoC3 compared with 9 patients (3.2%) with normal C3 levels (P = 0.11). However, 12 patients (18.2%) with hypoC3 reached D-SCr compared with 17 patients (6.1%) with normal C3 levels [Hazard ratio (HR), 3.59; 95% confidence interval (CI), 1.33-10.36; P = 0.018]. In a multivariable model in which serum C3 levels were treated as a continuous variable, hypoC3 significantly predicted renal outcome of D-SCr (per 1 mg/dl increase of C3; HR, 0.95; 95% CI, 0.92-0.99; P = 0.011). The risk of reaching renal outcome was significantly higher in patients with mesangial C3 deposition 2+ to 3+ than in patients without deposition (HR 9.37; 95% CI, 1.10-80.26; P = 0.04). Conclusions: This study showed that hypoC3 and mesangial C3 deposition were independent risk factors for progression, suggesting that complement activation may play a pathogenic role in patients with IgAN.

Original languageEnglish
Article numbere40495
JournalPloS one
Volume7
Issue number7
DOIs
Publication statusPublished - 2012 Jul 6

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kidney diseases
Immunoglobulin A
kidneys
Kidney
Creatinine
Hazards
creatinine
Biopsy
confidence interval
Serum
Confidence Intervals
Chronic Kidney Failure
Chemical activation
complement
Complement Activation
endpoints
cohort studies
Observational Studies
biopsy
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kim, Seung Jun ; Koo, Hyang Mo ; Lim, Beom Jin ; Oh, Hyung Jung ; Yoo, Dong Eun ; Shin, Dong Ho ; Lee, Mi Jung ; Doh, Fa Mee ; Park, Jung Tak ; Yoo, Tae Hyun ; Kang, Shin Wook ; Choi, Kyu Hun ; Jeong, Hyeon Joo ; Han, Seung Hyeok. / Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with iga nephropathy. In: PloS one. 2012 ; Vol. 7, No. 7.
@article{b03095ed2a484d4bb3362e62c2829721,
title = "Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with iga nephropathy",
abstract = "Background and Aims: Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN. Methods: A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr). Results: Of the patients, there were 66 patients (19.2{\%}) with hypoC3. During a mean follow-up of 53.7 months, ESRD occurred in 5 patients (7.6{\%}) with hypoC3 compared with 9 patients (3.2{\%}) with normal C3 levels (P = 0.11). However, 12 patients (18.2{\%}) with hypoC3 reached D-SCr compared with 17 patients (6.1{\%}) with normal C3 levels [Hazard ratio (HR), 3.59; 95{\%} confidence interval (CI), 1.33-10.36; P = 0.018]. In a multivariable model in which serum C3 levels were treated as a continuous variable, hypoC3 significantly predicted renal outcome of D-SCr (per 1 mg/dl increase of C3; HR, 0.95; 95{\%} CI, 0.92-0.99; P = 0.011). The risk of reaching renal outcome was significantly higher in patients with mesangial C3 deposition 2+ to 3+ than in patients without deposition (HR 9.37; 95{\%} CI, 1.10-80.26; P = 0.04). Conclusions: This study showed that hypoC3 and mesangial C3 deposition were independent risk factors for progression, suggesting that complement activation may play a pathogenic role in patients with IgAN.",
author = "Kim, {Seung Jun} and Koo, {Hyang Mo} and Lim, {Beom Jin} and Oh, {Hyung Jung} and Yoo, {Dong Eun} and Shin, {Dong Ho} and Lee, {Mi Jung} and Doh, {Fa Mee} and Park, {Jung Tak} and Yoo, {Tae Hyun} and Kang, {Shin Wook} and Choi, {Kyu Hun} and Jeong, {Hyeon Joo} and Han, {Seung Hyeok}",
year = "2012",
month = "7",
day = "6",
doi = "10.1371/journal.pone.0040495",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

Kim, SJ, Koo, HM, Lim, BJ, Oh, HJ, Yoo, DE, Shin, DH, Lee, MJ, Doh, FM, Park, JT, Yoo, TH, Kang, SW, Choi, KH, Jeong, HJ & Han, SH 2012, 'Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with iga nephropathy', PloS one, vol. 7, no. 7, e40495. https://doi.org/10.1371/journal.pone.0040495

Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with iga nephropathy. / Kim, Seung Jun; Koo, Hyang Mo; Lim, Beom Jin; Oh, Hyung Jung; Yoo, Dong Eun; Shin, Dong Ho; Lee, Mi Jung; Doh, Fa Mee; Park, Jung Tak; Yoo, Tae Hyun; Kang, Shin Wook; Choi, Kyu Hun; Jeong, Hyeon Joo; Han, Seung Hyeok.

In: PloS one, Vol. 7, No. 7, e40495, 06.07.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with iga nephropathy

AU - Kim, Seung Jun

AU - Koo, Hyang Mo

AU - Lim, Beom Jin

AU - Oh, Hyung Jung

AU - Yoo, Dong Eun

AU - Shin, Dong Ho

AU - Lee, Mi Jung

AU - Doh, Fa Mee

AU - Park, Jung Tak

AU - Yoo, Tae Hyun

AU - Kang, Shin Wook

AU - Choi, Kyu Hun

AU - Jeong, Hyeon Joo

AU - Han, Seung Hyeok

PY - 2012/7/6

Y1 - 2012/7/6

N2 - Background and Aims: Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN. Methods: A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr). Results: Of the patients, there were 66 patients (19.2%) with hypoC3. During a mean follow-up of 53.7 months, ESRD occurred in 5 patients (7.6%) with hypoC3 compared with 9 patients (3.2%) with normal C3 levels (P = 0.11). However, 12 patients (18.2%) with hypoC3 reached D-SCr compared with 17 patients (6.1%) with normal C3 levels [Hazard ratio (HR), 3.59; 95% confidence interval (CI), 1.33-10.36; P = 0.018]. In a multivariable model in which serum C3 levels were treated as a continuous variable, hypoC3 significantly predicted renal outcome of D-SCr (per 1 mg/dl increase of C3; HR, 0.95; 95% CI, 0.92-0.99; P = 0.011). The risk of reaching renal outcome was significantly higher in patients with mesangial C3 deposition 2+ to 3+ than in patients without deposition (HR 9.37; 95% CI, 1.10-80.26; P = 0.04). Conclusions: This study showed that hypoC3 and mesangial C3 deposition were independent risk factors for progression, suggesting that complement activation may play a pathogenic role in patients with IgAN.

AB - Background and Aims: Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of IgAN is uncertain. In this observational cohort study, we aimed to identify the clinical implications of circulating C3 levels and mesangial C3 deposition and to investigate their utility as predictors of renal outcomes in patients with IgAN. Methods: A total of 343 patients with biopsy-proven IgAN were enrolled between January 2000 and December 2008. Decreased serum C3 level (hypoC3) was defined as C3 <90 mg/dl. The study endpoint was end-stage renal disease (ESRD) and a doubling of the baseline serum creatinine (D-SCr). Results: Of the patients, there were 66 patients (19.2%) with hypoC3. During a mean follow-up of 53.7 months, ESRD occurred in 5 patients (7.6%) with hypoC3 compared with 9 patients (3.2%) with normal C3 levels (P = 0.11). However, 12 patients (18.2%) with hypoC3 reached D-SCr compared with 17 patients (6.1%) with normal C3 levels [Hazard ratio (HR), 3.59; 95% confidence interval (CI), 1.33-10.36; P = 0.018]. In a multivariable model in which serum C3 levels were treated as a continuous variable, hypoC3 significantly predicted renal outcome of D-SCr (per 1 mg/dl increase of C3; HR, 0.95; 95% CI, 0.92-0.99; P = 0.011). The risk of reaching renal outcome was significantly higher in patients with mesangial C3 deposition 2+ to 3+ than in patients without deposition (HR 9.37; 95% CI, 1.10-80.26; P = 0.04). Conclusions: This study showed that hypoC3 and mesangial C3 deposition were independent risk factors for progression, suggesting that complement activation may play a pathogenic role in patients with IgAN.

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