Abstract
Background: Although 30-50 % of patients with brain tumors experience epileptic seizure as the presenting clinical symptom, and another 10-30 % are at risk for developing epilepsy in the later stages of the disease, the mechanisms of tumor-related epileptogenesis are poorly understood. We used magnetoencephalography (MEG) to investigate sensory evoked fields (SEFs) in patients with frontal lobe brain tumors as a means of evaluating the neuronal activity of peri-tumoral cortex. Methods: Twelve patients with frontal lobe brain tumors underwent MEG. We calculated the equivalent current dipole strength of two components of the primary sensory cortical response (N20m and P35m) and compared the P35m/N20m ratio in the tumor hemisphere vs. the normal hemisphere. There were two subsets of patients: group I, in which P35m/N20m was higher in the tumor hemisphere (n = 7), and group II, in which P35m/N20m was higher in the normal hemisphere (n = 5). We looked for associations between clinical factors and P35m/N20m within each group. Results: All patients with seizure presentation were in group I, whereas only two patients without seizure presentation were in group I (Fisher exact test, p = 0.028). No other clinical factors were related to P35m/N20m. The mean ratio of P35m/N20m equivalent current dipole strength in patients with seizure presentation was 4.07 ± 2.38 in the tumor hemisphere and 2.00 ± 0.55 in the normal hemisphere. This difference was statistically significant (Mann-Whitney test, p = 0.030). Conclusion: The paradoxical increase in P35m/N20m in patients with seizure presentation suggests that decreased inhibitory neuronal activity is a potential cause of tumor-related epilepsy.
| Original language | English |
|---|---|
| Pages (from-to) | 1449-1457 |
| Number of pages | 9 |
| Journal | Acta Neurochirurgica |
| Volume | 155 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2013 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
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Decreased inhibitory neuronal activity in patients with frontal lobe brain tumors with seizure presentation : Preliminary study using magnetoencephalography. / Chang, Won Seok; Kim, Bong Soo; Jung, Hyun Ho; Kim, Kiwoong; Kwon, Hyuk Chan; Lee, Yong Ho; Chang, Jin Woo.
In: Acta Neurochirurgica, Vol. 155, No. 8, 01.08.2013, p. 1449-1457.Research output: Contribution to journal › Article
TY - JOUR
T1 - Decreased inhibitory neuronal activity in patients with frontal lobe brain tumors with seizure presentation
T2 - Preliminary study using magnetoencephalography
AU - Chang, Won Seok
AU - Kim, Bong Soo
AU - Jung, Hyun Ho
AU - Kim, Kiwoong
AU - Kwon, Hyuk Chan
AU - Lee, Yong Ho
AU - Chang, Jin Woo
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Background: Although 30-50 % of patients with brain tumors experience epileptic seizure as the presenting clinical symptom, and another 10-30 % are at risk for developing epilepsy in the later stages of the disease, the mechanisms of tumor-related epileptogenesis are poorly understood. We used magnetoencephalography (MEG) to investigate sensory evoked fields (SEFs) in patients with frontal lobe brain tumors as a means of evaluating the neuronal activity of peri-tumoral cortex. Methods: Twelve patients with frontal lobe brain tumors underwent MEG. We calculated the equivalent current dipole strength of two components of the primary sensory cortical response (N20m and P35m) and compared the P35m/N20m ratio in the tumor hemisphere vs. the normal hemisphere. There were two subsets of patients: group I, in which P35m/N20m was higher in the tumor hemisphere (n = 7), and group II, in which P35m/N20m was higher in the normal hemisphere (n = 5). We looked for associations between clinical factors and P35m/N20m within each group. Results: All patients with seizure presentation were in group I, whereas only two patients without seizure presentation were in group I (Fisher exact test, p = 0.028). No other clinical factors were related to P35m/N20m. The mean ratio of P35m/N20m equivalent current dipole strength in patients with seizure presentation was 4.07 ± 2.38 in the tumor hemisphere and 2.00 ± 0.55 in the normal hemisphere. This difference was statistically significant (Mann-Whitney test, p = 0.030). Conclusion: The paradoxical increase in P35m/N20m in patients with seizure presentation suggests that decreased inhibitory neuronal activity is a potential cause of tumor-related epilepsy.
AB - Background: Although 30-50 % of patients with brain tumors experience epileptic seizure as the presenting clinical symptom, and another 10-30 % are at risk for developing epilepsy in the later stages of the disease, the mechanisms of tumor-related epileptogenesis are poorly understood. We used magnetoencephalography (MEG) to investigate sensory evoked fields (SEFs) in patients with frontal lobe brain tumors as a means of evaluating the neuronal activity of peri-tumoral cortex. Methods: Twelve patients with frontal lobe brain tumors underwent MEG. We calculated the equivalent current dipole strength of two components of the primary sensory cortical response (N20m and P35m) and compared the P35m/N20m ratio in the tumor hemisphere vs. the normal hemisphere. There were two subsets of patients: group I, in which P35m/N20m was higher in the tumor hemisphere (n = 7), and group II, in which P35m/N20m was higher in the normal hemisphere (n = 5). We looked for associations between clinical factors and P35m/N20m within each group. Results: All patients with seizure presentation were in group I, whereas only two patients without seizure presentation were in group I (Fisher exact test, p = 0.028). No other clinical factors were related to P35m/N20m. The mean ratio of P35m/N20m equivalent current dipole strength in patients with seizure presentation was 4.07 ± 2.38 in the tumor hemisphere and 2.00 ± 0.55 in the normal hemisphere. This difference was statistically significant (Mann-Whitney test, p = 0.030). Conclusion: The paradoxical increase in P35m/N20m in patients with seizure presentation suggests that decreased inhibitory neuronal activity is a potential cause of tumor-related epilepsy.
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U2 - 10.1007/s00701-013-1781-2
DO - 10.1007/s00701-013-1781-2
M3 - Article
C2 - 23797730
AN - SCOPUS:84880764568
VL - 155
SP - 1449
EP - 1457
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
IS - 8
ER -