Decreased insulin sensitivity is associated with the extent of coronary artery disease in patients with angina

Kihwan Kwon, D. Choi, B. K. Koo, S. K. Ryu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Insulin resistance has been proposed as an important risk factor in the development of atherosclerosis. Aim: To evaluate the association of insulin resistance and coronary atherosclerosis, we investigated the correlation between insulin sensitivity and the degree of coronary stenosis in patients with angina pectoris. Methods: The study population consisted of 74 subjects with angina (54 men and 20 women) aged from 31 to 73 years. Coronary angiograms were evaluated by three semiquantitative scoring systems (vessel score, stenosis score and extent score) to estimate the extent of focal and diffuse coronary artery disease (CAD). Insulin sensitivity (KITT) was determined by the insulin tolerance test. Results: There were significant correlations existed between KITT and all three coronary scores. Multivariate analysis revealed significant and independent correlations of all three coronary scores with KITT (vessel score: β = -0.349, p = 0.004; stenosis score: β = -0.487, p < 0.001; extent score: β = -0.481, p < 0.001), even in patients without diabetes mellitus (vessel score: β = -0.387, p = 0.008; stenosis score: β = -0.469, p < 0.001; extent score: β = -0.559, p < 0.001). KITT was significantly lower in patient with diffuse CAD than without diffuse CAD (2.13 ± 0.66 vs. 2.57 ± 0.79%/min, p < 0.05). However, KITT was not different between patients with and without focal CAD. Conclusions: Insulin sensitivity has statistically significant and independent associations with the extent of coronary stenosis. These results suggest that insulin resistance may play a major role in the development of diffuse coronary artery stenosis.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalDiabetes, Obesity and Metabolism
Volume7
Issue number5
DOIs
Publication statusPublished - 2005 Sep

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Insulin Resistance
Coronary Artery Disease
Coronary Stenosis
Pathologic Constriction
Angina Pectoris
Atherosclerosis
Diabetes Mellitus
Angiography
Multivariate Analysis
Insulin
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Decreased insulin sensitivity is associated with the extent of coronary artery disease in patients with angina",
abstract = "Background: Insulin resistance has been proposed as an important risk factor in the development of atherosclerosis. Aim: To evaluate the association of insulin resistance and coronary atherosclerosis, we investigated the correlation between insulin sensitivity and the degree of coronary stenosis in patients with angina pectoris. Methods: The study population consisted of 74 subjects with angina (54 men and 20 women) aged from 31 to 73 years. Coronary angiograms were evaluated by three semiquantitative scoring systems (vessel score, stenosis score and extent score) to estimate the extent of focal and diffuse coronary artery disease (CAD). Insulin sensitivity (KITT) was determined by the insulin tolerance test. Results: There were significant correlations existed between KITT and all three coronary scores. Multivariate analysis revealed significant and independent correlations of all three coronary scores with KITT (vessel score: β = -0.349, p = 0.004; stenosis score: β = -0.487, p < 0.001; extent score: β = -0.481, p < 0.001), even in patients without diabetes mellitus (vessel score: β = -0.387, p = 0.008; stenosis score: β = -0.469, p < 0.001; extent score: β = -0.559, p < 0.001). KITT was significantly lower in patient with diffuse CAD than without diffuse CAD (2.13 ± 0.66 vs. 2.57 ± 0.79{\%}/min, p < 0.05). However, KITT was not different between patients with and without focal CAD. Conclusions: Insulin sensitivity has statistically significant and independent associations with the extent of coronary stenosis. These results suggest that insulin resistance may play a major role in the development of diffuse coronary artery stenosis.",
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Decreased insulin sensitivity is associated with the extent of coronary artery disease in patients with angina. / Kwon, Kihwan; Choi, D.; Koo, B. K.; Ryu, S. K.

In: Diabetes, Obesity and Metabolism, Vol. 7, No. 5, 09.2005, p. 579-585.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decreased insulin sensitivity is associated with the extent of coronary artery disease in patients with angina

AU - Kwon, Kihwan

AU - Choi, D.

AU - Koo, B. K.

AU - Ryu, S. K.

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Y1 - 2005/9

N2 - Background: Insulin resistance has been proposed as an important risk factor in the development of atherosclerosis. Aim: To evaluate the association of insulin resistance and coronary atherosclerosis, we investigated the correlation between insulin sensitivity and the degree of coronary stenosis in patients with angina pectoris. Methods: The study population consisted of 74 subjects with angina (54 men and 20 women) aged from 31 to 73 years. Coronary angiograms were evaluated by three semiquantitative scoring systems (vessel score, stenosis score and extent score) to estimate the extent of focal and diffuse coronary artery disease (CAD). Insulin sensitivity (KITT) was determined by the insulin tolerance test. Results: There were significant correlations existed between KITT and all three coronary scores. Multivariate analysis revealed significant and independent correlations of all three coronary scores with KITT (vessel score: β = -0.349, p = 0.004; stenosis score: β = -0.487, p < 0.001; extent score: β = -0.481, p < 0.001), even in patients without diabetes mellitus (vessel score: β = -0.387, p = 0.008; stenosis score: β = -0.469, p < 0.001; extent score: β = -0.559, p < 0.001). KITT was significantly lower in patient with diffuse CAD than without diffuse CAD (2.13 ± 0.66 vs. 2.57 ± 0.79%/min, p < 0.05). However, KITT was not different between patients with and without focal CAD. Conclusions: Insulin sensitivity has statistically significant and independent associations with the extent of coronary stenosis. These results suggest that insulin resistance may play a major role in the development of diffuse coronary artery stenosis.

AB - Background: Insulin resistance has been proposed as an important risk factor in the development of atherosclerosis. Aim: To evaluate the association of insulin resistance and coronary atherosclerosis, we investigated the correlation between insulin sensitivity and the degree of coronary stenosis in patients with angina pectoris. Methods: The study population consisted of 74 subjects with angina (54 men and 20 women) aged from 31 to 73 years. Coronary angiograms were evaluated by three semiquantitative scoring systems (vessel score, stenosis score and extent score) to estimate the extent of focal and diffuse coronary artery disease (CAD). Insulin sensitivity (KITT) was determined by the insulin tolerance test. Results: There were significant correlations existed between KITT and all three coronary scores. Multivariate analysis revealed significant and independent correlations of all three coronary scores with KITT (vessel score: β = -0.349, p = 0.004; stenosis score: β = -0.487, p < 0.001; extent score: β = -0.481, p < 0.001), even in patients without diabetes mellitus (vessel score: β = -0.387, p = 0.008; stenosis score: β = -0.469, p < 0.001; extent score: β = -0.559, p < 0.001). KITT was significantly lower in patient with diffuse CAD than without diffuse CAD (2.13 ± 0.66 vs. 2.57 ± 0.79%/min, p < 0.05). However, KITT was not different between patients with and without focal CAD. Conclusions: Insulin sensitivity has statistically significant and independent associations with the extent of coronary stenosis. These results suggest that insulin resistance may play a major role in the development of diffuse coronary artery stenosis.

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