Decreased macrophage density on carbon nanotube patterns on polycarbonate urethane

Youl Kim Jong, Dongwoo Khang, Jongeun Lee, Thomas J. Webster

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Nanotechnology is creating materials that can regenerate numerous tissues (including those used for bone, vascular, cartilage, bladder, and neuronal systems) better than what is currently being implanted. Despite this promise, little is known about the functions of wound healing cells (such as macrophages) on nanomaterials. Carbon nanotubes are intriguing nanomaterials for implantation due to their unique biologically inspired surface, electrical, and mechanical properties. For the above reasons, the objective of the present study was to investigate macrophage function on one promising type of nano-implant material for orthopedic applications (carbon nanotubes microscopically aligned on polymers). To align carbon nanotubes on polymers, a novel imprinting method placing carbon nanotubes in grids of defined spacings (from 30 to 100 μm) on a polymer matrix was developed. In this study, the selective adhesion and proliferation of macrophages after 4 h, 24 h, and 4 days on aligned regions of a currently implanted polymer (specifically, polycarbonate urethane) compared to aligned carbon nanotube patterns were found. That is, decreased macrophage functions were observed in this study on aligned regions of carbon nanotubes compared to polycarbonate urethane. The present in vitro study, thus, provided evidence of the ability of carbon nanotubes to down-regulate macrophage adhesion and proliferation which is important to decrease a harmful persistence wound-healing reaction to orthopedic implants.

Original languageEnglish
Pages (from-to)419-426
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume88
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1

Fingerprint

polycarbonate
Carbon Nanotubes
Macrophages
Urethane
Polycarbonates
Carbon nanotubes
Polymers
Orthopedics
Nanostructured materials
Adhesion
Cartilage
Polymer matrix
Nanotechnology
Surface properties

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

Jong, Youl Kim ; Khang, Dongwoo ; Lee, Jongeun ; Webster, Thomas J. / Decreased macrophage density on carbon nanotube patterns on polycarbonate urethane. In: Journal of Biomedical Materials Research - Part A. 2009 ; Vol. 88, No. 2. pp. 419-426.
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Decreased macrophage density on carbon nanotube patterns on polycarbonate urethane. / Jong, Youl Kim; Khang, Dongwoo; Lee, Jongeun; Webster, Thomas J.

In: Journal of Biomedical Materials Research - Part A, Vol. 88, No. 2, 01.02.2009, p. 419-426.

Research output: Contribution to journalArticle

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