Abstract
Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min/1.73 m2. In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34 months (8-50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r = - 0.304, P = 0.001; r = 0.042, P = 0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r = - 0.219, P = 0.008). In the normoalbuminuria group (n = 63), the plasma α-klotho remained significantly associated with a decline in eGFR (r = 0.324, P = 0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 887-892 |
| Number of pages | 6 |
| Journal | Journal of Diabetes and its Complications |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2016 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients. / Kim, Sang Soo; Song, Sang Heon; Kim, In Joo; Lee, Eun Young; Lee, Su Mi; Chung, Choon Hee; Kwak, Ihm Soo; Lee, Eun Kyung; Kim, Yong Ki.
In: Journal of Diabetes and its Complications, Vol. 30, No. 5, 01.07.2016, p. 887-892.Research output: Contribution to journal › Article
TY - JOUR
T1 - Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients
AU - Kim, Sang Soo
AU - Song, Sang Heon
AU - Kim, In Joo
AU - Lee, Eun Young
AU - Lee, Su Mi
AU - Chung, Choon Hee
AU - Kwak, Ihm Soo
AU - Lee, Eun Kyung
AU - Kim, Yong Ki
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min/1.73 m2. In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34 months (8-50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r = - 0.304, P = 0.001; r = 0.042, P = 0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r = - 0.219, P = 0.008). In the normoalbuminuria group (n = 63), the plasma α-klotho remained significantly associated with a decline in eGFR (r = 0.324, P = 0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
AB - Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min/1.73 m2. In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34 months (8-50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r = - 0.304, P = 0.001; r = 0.042, P = 0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r = - 0.219, P = 0.008). In the normoalbuminuria group (n = 63), the plasma α-klotho remained significantly associated with a decline in eGFR (r = 0.324, P = 0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
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U2 - 10.1016/j.jdiacomp.2016.03.006
DO - 10.1016/j.jdiacomp.2016.03.006
M3 - Article
VL - 30
SP - 887
EP - 892
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 5
ER -