Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients

Sang Soo Kim, Sang Heon Song, In Joo Kim, Eun Young Lee, Su Mi Lee, Choon Hee Chung, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim

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Abstract

Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min/1.73 m2. In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34 months (8-50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r = - 0.304, P = 0.001; r = 0.042, P = 0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r = - 0.219, P = 0.008). In the normoalbuminuria group (n = 63), the plasma α-klotho remained significantly associated with a decline in eGFR (r = 0.324, P = 0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.

Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalJournal of Diabetes and its Complications
Volume30
Issue number5
DOIs
Publication statusPublished - 2016 Jul 1

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Glomerular Filtration Rate
Diabetic Nephropathies
Urine
Type 2 Diabetes Mellitus
Observational Studies
Biomarkers
Prospective Studies
Kidney

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kim, Sang Soo ; Song, Sang Heon ; Kim, In Joo ; Lee, Eun Young ; Lee, Su Mi ; Chung, Choon Hee ; Kwak, Ihm Soo ; Lee, Eun Kyung ; Kim, Yong Ki. / Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients. In: Journal of Diabetes and its Complications. 2016 ; Vol. 30, No. 5. pp. 887-892.
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Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients. / Kim, Sang Soo; Song, Sang Heon; Kim, In Joo; Lee, Eun Young; Lee, Su Mi; Chung, Choon Hee; Kwak, Ihm Soo; Lee, Eun Kyung; Kim, Yong Ki.

In: Journal of Diabetes and its Complications, Vol. 30, No. 5, 01.07.2016, p. 887-892.

Research output: Contribution to journalArticle

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AU - Song, Sang Heon

AU - Kim, In Joo

AU - Lee, Eun Young

AU - Lee, Su Mi

AU - Chung, Choon Hee

AU - Kwak, Ihm Soo

AU - Lee, Eun Kyung

AU - Kim, Yong Ki

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N2 - Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min/1.73 m2. In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34 months (8-50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r = - 0.304, P = 0.001; r = 0.042, P = 0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r = - 0.219, P = 0.008). In the normoalbuminuria group (n = 63), the plasma α-klotho remained significantly associated with a decline in eGFR (r = 0.324, P = 0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.

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