Abstract
The root of Angelica gigas Nakai contains two major coumarins, which have been previously identified as decursin and decursinol. Decursin has been demonstrated to exhibit potent anti-cancer activity both in vitro and in vivo. In this study, we found that decursin and decursinol at non-cytotoxic doses inhibited the VEGF-induced proliferation, migration, and capillary-tube formation of HUVECs. Moreover, decursin and decursinol suppressed microvessel formation on chorioallantoic membranes in fertilized eggs and into mouse Matrigel plugs. The oral administration of decursin and decursinol also reduced VEGF-induced angiogenesis in Matrigel. Furthermore, decursin and decursinol reduced the phosphorylation of ERK and JNK, but not p38 MAPK, in VEGF-stimulated HUVECs. Taken together, our results reveal that decursin and decursinol inhibit VEGF-induced angiogenesis by reducing the activation of ERK and JNK in HUVECs, and possess potent in vivo anti-angiogenic activity, coupled with the advantage of oral dosing. Thus, these compounds may have the potential for the treatment of cancers dependent on VEGF-induced vascularization.
| Original language | English |
|---|---|
| Pages (from-to) | 86-92 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 280 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 Jul 18 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
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Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. / Son, Seung Hwa; Kim, Mi Jeong; Chung, Won Yoon; Son, Ju Ah; Kim, Yeong Shik; Kim, Young Choong; Kang, Sam Sik; Lee, Sang Kook; Park, Kwang Kyun.
In: Cancer Letters, Vol. 280, No. 1, 18.07.2009, p. 86-92.Research output: Contribution to journal › Article
TY - JOUR
T1 - Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase
AU - Son, Seung Hwa
AU - Kim, Mi Jeong
AU - Chung, Won Yoon
AU - Son, Ju Ah
AU - Kim, Yeong Shik
AU - Kim, Young Choong
AU - Kang, Sam Sik
AU - Lee, Sang Kook
AU - Park, Kwang Kyun
PY - 2009/7/18
Y1 - 2009/7/18
N2 - The root of Angelica gigas Nakai contains two major coumarins, which have been previously identified as decursin and decursinol. Decursin has been demonstrated to exhibit potent anti-cancer activity both in vitro and in vivo. In this study, we found that decursin and decursinol at non-cytotoxic doses inhibited the VEGF-induced proliferation, migration, and capillary-tube formation of HUVECs. Moreover, decursin and decursinol suppressed microvessel formation on chorioallantoic membranes in fertilized eggs and into mouse Matrigel plugs. The oral administration of decursin and decursinol also reduced VEGF-induced angiogenesis in Matrigel. Furthermore, decursin and decursinol reduced the phosphorylation of ERK and JNK, but not p38 MAPK, in VEGF-stimulated HUVECs. Taken together, our results reveal that decursin and decursinol inhibit VEGF-induced angiogenesis by reducing the activation of ERK and JNK in HUVECs, and possess potent in vivo anti-angiogenic activity, coupled with the advantage of oral dosing. Thus, these compounds may have the potential for the treatment of cancers dependent on VEGF-induced vascularization.
AB - The root of Angelica gigas Nakai contains two major coumarins, which have been previously identified as decursin and decursinol. Decursin has been demonstrated to exhibit potent anti-cancer activity both in vitro and in vivo. In this study, we found that decursin and decursinol at non-cytotoxic doses inhibited the VEGF-induced proliferation, migration, and capillary-tube formation of HUVECs. Moreover, decursin and decursinol suppressed microvessel formation on chorioallantoic membranes in fertilized eggs and into mouse Matrigel plugs. The oral administration of decursin and decursinol also reduced VEGF-induced angiogenesis in Matrigel. Furthermore, decursin and decursinol reduced the phosphorylation of ERK and JNK, but not p38 MAPK, in VEGF-stimulated HUVECs. Taken together, our results reveal that decursin and decursinol inhibit VEGF-induced angiogenesis by reducing the activation of ERK and JNK in HUVECs, and possess potent in vivo anti-angiogenic activity, coupled with the advantage of oral dosing. Thus, these compounds may have the potential for the treatment of cancers dependent on VEGF-induced vascularization.
UR - http://www.scopus.com/inward/record.url?scp=67349245011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349245011&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2009.02.012
DO - 10.1016/j.canlet.2009.02.012
M3 - Article
C2 - 19307054
AN - SCOPUS:67349245011
VL - 280
SP - 86
EP - 92
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -