Abstract
von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 471-476 |
| Number of pages | 6 |
| Journal | Thrombosis Research |
| Volume | 105 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2002 Mar 15 |
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All Science Journal Classification (ASJC) codes
- Hematology
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Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients. / Koo, Bon Hun; Oh, Doyeun; Chung, So Young; Kim, Nam Keun; Park, Seonyang; Jang, Yangsoo; Chung, Kwang Hoe.
In: Thrombosis Research, Vol. 105, No. 6, 15.03.2002, p. 471-476.Research output: Contribution to journal › Article
TY - JOUR
T1 - Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients
AU - Koo, Bon Hun
AU - Oh, Doyeun
AU - Chung, So Young
AU - Kim, Nam Keun
AU - Park, Seonyang
AU - Jang, Yangsoo
AU - Chung, Kwang Hoe
PY - 2002/3/15
Y1 - 2002/3/15
N2 - von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.
AB - von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.
UR - http://www.scopus.com/inward/record.url?scp=0037085694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037085694&partnerID=8YFLogxK
U2 - 10.1016/S0049-3848(02)00053-1
DO - 10.1016/S0049-3848(02)00053-1
M3 - Article
C2 - 12091044
AN - SCOPUS:0037085694
VL - 105
SP - 471
EP - 476
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 6
ER -