Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients

Bon Hun Koo, Doyeun Oh, So Young Chung, Nam Keun Kim, Seonyang Park, Yangsoo Jang, Kwang Hoe Chung

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalThrombosis Research
Volume105
Issue number6
DOIs
Publication statusPublished - 2002 Mar 15

All Science Journal Classification (ASJC) codes

  • Hematology

Fingerprint Dive into the research topics of 'Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients'. Together they form a unique fingerprint.

Cite this