Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients

Bon Hun Koo; Doyeun Oh; So Young Chung; Nam Keun Kim; Seonyang Park; Yangsoo Jang; Kwang Hoe Chung

doi:10.1016/S0049-3848(02)00053-1

Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients

Bon Hun Koo, Doyeun Oh, So Young Chung, Nam Keun Kim, Seonyang Park, Yangsoo Jang, Kwang Hoe Chung

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.

Original language	English
Pages (from-to)	471-476
Number of pages	6
Journal	Thrombosis Research
Volume	105
Issue number	6
DOIs	https://doi.org/10.1016/S0049-3848(02)00053-1
Publication status	Published - 2002 Mar 15

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Hematology

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title = "Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients",

abstract = "von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.",

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AU - Koo, Bon Hun

AU - Oh, Doyeun

AU - Chung, So Young

AU - Kim, Nam Keun

AU - Park, Seonyang

AU - Jang, Yangsoo

AU - Chung, Kwang Hoe

PY - 2002/3/15

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N2 - von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.

AB - von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease.

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Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients

Abstract

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