TY - JOUR
T1 - Deformylative Intramolecular Hydroarylation
T2 - Synthesis of Benzo[e]pyrido[1,2-a]indoles
AU - Jung, Youngeun
AU - Kim, Ikyon
N1 - Publisher Copyright:
© 2015 American Chemical Society.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/9/18
Y1 - 2015/9/18
N2 - Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[e]pyrido[1,2-a]indoles with an aryl substituent at the C6 position as major products, along with the expected C5-acylated benzo[e]pyrido[1,2-a]indoles as minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead of intended alkyne-carbonyl metathesis.
AB - Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[e]pyrido[1,2-a]indoles with an aryl substituent at the C6 position as major products, along with the expected C5-acylated benzo[e]pyrido[1,2-a]indoles as minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead of intended alkyne-carbonyl metathesis.
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U2 - 10.1021/acs.orglett.5b02331
DO - 10.1021/acs.orglett.5b02331
M3 - Article
AN - SCOPUS:84941899101
VL - 17
SP - 4600
EP - 4603
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 18
ER -