Abstract
Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[e]pyrido[1,2-a]indoles with an aryl substituent at the C6 position as major products, along with the expected C5-acylated benzo[e]pyrido[1,2-a]indoles as minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead of intended alkyne-carbonyl metathesis.
| Original language | English |
|---|---|
| Pages (from-to) | 4600-4603 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 17 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2015 Sep 18 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
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Deformylative Intramolecular Hydroarylation : Synthesis of Benzo[e]pyrido[1,2-a]indoles. / Jung, Youngeun; Kim, Ikyon.
In: Organic Letters, Vol. 17, No. 18, 18.09.2015, p. 4600-4603.Research output: Contribution to journal › Article
TY - JOUR
T1 - Deformylative Intramolecular Hydroarylation
T2 - Synthesis of Benzo[e]pyrido[1,2-a]indoles
AU - Jung, Youngeun
AU - Kim, Ikyon
PY - 2015/9/18
Y1 - 2015/9/18
N2 - Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[e]pyrido[1,2-a]indoles with an aryl substituent at the C6 position as major products, along with the expected C5-acylated benzo[e]pyrido[1,2-a]indoles as minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead of intended alkyne-carbonyl metathesis.
AB - Attempted cyclization of indolizines bearing both formyl and alkyne groups under acid catalysis provided benzo[e]pyrido[1,2-a]indoles with an aryl substituent at the C6 position as major products, along with the expected C5-acylated benzo[e]pyrido[1,2-a]indoles as minor ones, which resulted from preferential deformylative intramolecular hydroarylation instead of intended alkyne-carbonyl metathesis.
UR - http://www.scopus.com/inward/record.url?scp=84941899101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941899101&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.5b02331
DO - 10.1021/acs.orglett.5b02331
M3 - Article
AN - SCOPUS:84941899101
VL - 17
SP - 4600
EP - 4603
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 18
ER -