Degeneration of leiomyoma in patients referred for uterine fibroid embolization: Incidence, imaging features and clinical characteristics

Seung Chul Han, Man Deuk Kim, Dae Chul Jung, Myungsu Lee, Mu Sook Lee, Sung Il Park, Jong Yun Won, Do Yun Lee, Kwang Hun Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Imaging features and clinical characteristics of degenerated leiomyoma in patients referred for uterine fibroid embolization (UFE) were analyzed to assess the incidence of degenerated leiomyoma. Materials and Methods: Patients referred for UFE between 2008 and 2009 were retrospectively analyzed (n=276). Patients ranged in age from 27 to 51 years (mean 38.0 years). All patients underwent screening MRI with contrast enhancement. Medical histories and clinical symptoms were evaluated. Results: Among the 276 patients who underwent MRI, 14 (5.1%) showed degenerated leiomyomas. Symptoms were abdominal pain (n=4, 26.7%), menorrhagia (n=5, 35.7%) and bulk-related symptoms (n=5, 35.7%) and no symptoms (n=5, 35.7%). Of the 14 patients with degenerated leiomyomas, 5 (42.9%) had a history of pregnancy in the past two years. For T1weighted imaging (T1WI), a high signal intensity (SI) of the leiomyoma was the most common finding (n=9, 64.3%) and a hyperintense rim (n=4, 28.6%) was the second most common. On T2-weighted imaging (T2WI), a low SI of the leiomyoma was found in six patients (42.9%), a high SI in four (28.6%) and a heterogeneous SI in four (28.6%) patients. Conservative management was performed in 11 (78.6%) patients, surgery in 3 (21.4%) and uterine artery embolization in one (7.1%) patient. Conclusion: The incidence of degeneration of leiomyoma in patients referred for UFE was 5.1%. Patients presented with variable clinical symptoms with or without a history of pregnancy. MR imaging showed a high SI on T1WI and various SIs on T2WI without contrast enhancement. An understanding of the degeneration of leiomyomata is essential when considering UFE.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalYonsei medical journal
Volume54
Issue number1
DOIs
Publication statusPublished - 2013 Jan

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Leiomyoma
Incidence
Reproductive History
Uterine Artery Embolization
Menorrhagia
Abdominal Pain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Han, Seung Chul ; Kim, Man Deuk ; Jung, Dae Chul ; Lee, Myungsu ; Lee, Mu Sook ; Park, Sung Il ; Won, Jong Yun ; Lee, Do Yun ; Lee, Kwang Hun. / Degeneration of leiomyoma in patients referred for uterine fibroid embolization : Incidence, imaging features and clinical characteristics. In: Yonsei medical journal. 2013 ; Vol. 54, No. 1. pp. 215-219.
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title = "Degeneration of leiomyoma in patients referred for uterine fibroid embolization: Incidence, imaging features and clinical characteristics",
abstract = "Purpose: Imaging features and clinical characteristics of degenerated leiomyoma in patients referred for uterine fibroid embolization (UFE) were analyzed to assess the incidence of degenerated leiomyoma. Materials and Methods: Patients referred for UFE between 2008 and 2009 were retrospectively analyzed (n=276). Patients ranged in age from 27 to 51 years (mean 38.0 years). All patients underwent screening MRI with contrast enhancement. Medical histories and clinical symptoms were evaluated. Results: Among the 276 patients who underwent MRI, 14 (5.1{\%}) showed degenerated leiomyomas. Symptoms were abdominal pain (n=4, 26.7{\%}), menorrhagia (n=5, 35.7{\%}) and bulk-related symptoms (n=5, 35.7{\%}) and no symptoms (n=5, 35.7{\%}). Of the 14 patients with degenerated leiomyomas, 5 (42.9{\%}) had a history of pregnancy in the past two years. For T1weighted imaging (T1WI), a high signal intensity (SI) of the leiomyoma was the most common finding (n=9, 64.3{\%}) and a hyperintense rim (n=4, 28.6{\%}) was the second most common. On T2-weighted imaging (T2WI), a low SI of the leiomyoma was found in six patients (42.9{\%}), a high SI in four (28.6{\%}) and a heterogeneous SI in four (28.6{\%}) patients. Conservative management was performed in 11 (78.6{\%}) patients, surgery in 3 (21.4{\%}) and uterine artery embolization in one (7.1{\%}) patient. Conclusion: The incidence of degeneration of leiomyoma in patients referred for UFE was 5.1{\%}. Patients presented with variable clinical symptoms with or without a history of pregnancy. MR imaging showed a high SI on T1WI and various SIs on T2WI without contrast enhancement. An understanding of the degeneration of leiomyomata is essential when considering UFE.",
author = "Han, {Seung Chul} and Kim, {Man Deuk} and Jung, {Dae Chul} and Myungsu Lee and Lee, {Mu Sook} and Park, {Sung Il} and Won, {Jong Yun} and Lee, {Do Yun} and Lee, {Kwang Hun}",
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Degeneration of leiomyoma in patients referred for uterine fibroid embolization : Incidence, imaging features and clinical characteristics. / Han, Seung Chul; Kim, Man Deuk; Jung, Dae Chul; Lee, Myungsu; Lee, Mu Sook; Park, Sung Il; Won, Jong Yun; Lee, Do Yun; Lee, Kwang Hun.

In: Yonsei medical journal, Vol. 54, No. 1, 01.2013, p. 215-219.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Degeneration of leiomyoma in patients referred for uterine fibroid embolization

T2 - Incidence, imaging features and clinical characteristics

AU - Han, Seung Chul

AU - Kim, Man Deuk

AU - Jung, Dae Chul

AU - Lee, Myungsu

AU - Lee, Mu Sook

AU - Park, Sung Il

AU - Won, Jong Yun

AU - Lee, Do Yun

AU - Lee, Kwang Hun

PY - 2013/1

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N2 - Purpose: Imaging features and clinical characteristics of degenerated leiomyoma in patients referred for uterine fibroid embolization (UFE) were analyzed to assess the incidence of degenerated leiomyoma. Materials and Methods: Patients referred for UFE between 2008 and 2009 were retrospectively analyzed (n=276). Patients ranged in age from 27 to 51 years (mean 38.0 years). All patients underwent screening MRI with contrast enhancement. Medical histories and clinical symptoms were evaluated. Results: Among the 276 patients who underwent MRI, 14 (5.1%) showed degenerated leiomyomas. Symptoms were abdominal pain (n=4, 26.7%), menorrhagia (n=5, 35.7%) and bulk-related symptoms (n=5, 35.7%) and no symptoms (n=5, 35.7%). Of the 14 patients with degenerated leiomyomas, 5 (42.9%) had a history of pregnancy in the past two years. For T1weighted imaging (T1WI), a high signal intensity (SI) of the leiomyoma was the most common finding (n=9, 64.3%) and a hyperintense rim (n=4, 28.6%) was the second most common. On T2-weighted imaging (T2WI), a low SI of the leiomyoma was found in six patients (42.9%), a high SI in four (28.6%) and a heterogeneous SI in four (28.6%) patients. Conservative management was performed in 11 (78.6%) patients, surgery in 3 (21.4%) and uterine artery embolization in one (7.1%) patient. Conclusion: The incidence of degeneration of leiomyoma in patients referred for UFE was 5.1%. Patients presented with variable clinical symptoms with or without a history of pregnancy. MR imaging showed a high SI on T1WI and various SIs on T2WI without contrast enhancement. An understanding of the degeneration of leiomyomata is essential when considering UFE.

AB - Purpose: Imaging features and clinical characteristics of degenerated leiomyoma in patients referred for uterine fibroid embolization (UFE) were analyzed to assess the incidence of degenerated leiomyoma. Materials and Methods: Patients referred for UFE between 2008 and 2009 were retrospectively analyzed (n=276). Patients ranged in age from 27 to 51 years (mean 38.0 years). All patients underwent screening MRI with contrast enhancement. Medical histories and clinical symptoms were evaluated. Results: Among the 276 patients who underwent MRI, 14 (5.1%) showed degenerated leiomyomas. Symptoms were abdominal pain (n=4, 26.7%), menorrhagia (n=5, 35.7%) and bulk-related symptoms (n=5, 35.7%) and no symptoms (n=5, 35.7%). Of the 14 patients with degenerated leiomyomas, 5 (42.9%) had a history of pregnancy in the past two years. For T1weighted imaging (T1WI), a high signal intensity (SI) of the leiomyoma was the most common finding (n=9, 64.3%) and a hyperintense rim (n=4, 28.6%) was the second most common. On T2-weighted imaging (T2WI), a low SI of the leiomyoma was found in six patients (42.9%), a high SI in four (28.6%) and a heterogeneous SI in four (28.6%) patients. Conservative management was performed in 11 (78.6%) patients, surgery in 3 (21.4%) and uterine artery embolization in one (7.1%) patient. Conclusion: The incidence of degeneration of leiomyoma in patients referred for UFE was 5.1%. Patients presented with variable clinical symptoms with or without a history of pregnancy. MR imaging showed a high SI on T1WI and various SIs on T2WI without contrast enhancement. An understanding of the degeneration of leiomyomata is essential when considering UFE.

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