Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle

Su Jin Kim, Hong Min Kim, Eun Soo Lee, Nami Kim, Jung Ok Lee, Hye Jeong Lee, Na Yeon Park, Joo Yeon Jo, Bo Young Ham, Si Hyun Han, Sun Hwa Park, Choon Hee Chung, Hyeon Soo Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dehydrozingerone (DHZ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high-fat diet-induced weight gain, lipid accumulation and hyperglycaemia in C57BL/6 mice and increased AMP-activated protein kinase (AMPK) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen-activated protein kinase (MAPK) signalling in an AMPK-dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ-induced glucose uptake. DHZ increased GLUT4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin-induced glucose uptake increased in DHZ-fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo. Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle.

Original languageEnglish
Pages (from-to)620-629
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume19
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

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Obese Mice
AMP-Activated Protein Kinases
High Fat Diet
Skeletal Muscle
Glucose
p38 Mitogen-Activated Protein Kinases
Facilitative Glucose Transport Proteins
methyl-3-methoxy-4-hydroxystyryl ketone
Health
Inbred C57BL Mouse
Hyperglycemia
Muscle Cells
Weight Gain
Insulin Resistance
Phosphorylation
Insulin
Lipids

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cell Biology

Cite this

Kim, Su Jin ; Kim, Hong Min ; Lee, Eun Soo ; Kim, Nami ; Lee, Jung Ok ; Lee, Hye Jeong ; Park, Na Yeon ; Jo, Joo Yeon ; Ham, Bo Young ; Han, Si Hyun ; Park, Sun Hwa ; Chung, Choon Hee ; Kim, Hyeon Soo. / Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle. In: Journal of Cellular and Molecular Medicine. 2015 ; Vol. 19, No. 3. pp. 620-629.
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abstract = "Dehydrozingerone (DHZ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high-fat diet-induced weight gain, lipid accumulation and hyperglycaemia in C57BL/6 mice and increased AMP-activated protein kinase (AMPK) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen-activated protein kinase (MAPK) signalling in an AMPK-dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ-induced glucose uptake. DHZ increased GLUT4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin-induced glucose uptake increased in DHZ-fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo. Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle.",
author = "Kim, {Su Jin} and Kim, {Hong Min} and Lee, {Eun Soo} and Nami Kim and Lee, {Jung Ok} and Lee, {Hye Jeong} and Park, {Na Yeon} and Jo, {Joo Yeon} and Ham, {Bo Young} and Han, {Si Hyun} and Park, {Sun Hwa} and Chung, {Choon Hee} and Kim, {Hyeon Soo}",
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Kim, SJ, Kim, HM, Lee, ES, Kim, N, Lee, JO, Lee, HJ, Park, NY, Jo, JY, Ham, BY, Han, SH, Park, SH, Chung, CH & Kim, HS 2015, 'Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle', Journal of Cellular and Molecular Medicine, vol. 19, no. 3, pp. 620-629. https://doi.org/10.1111/jcmm.12455

Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle. / Kim, Su Jin; Kim, Hong Min; Lee, Eun Soo; Kim, Nami; Lee, Jung Ok; Lee, Hye Jeong; Park, Na Yeon; Jo, Joo Yeon; Ham, Bo Young; Han, Si Hyun; Park, Sun Hwa; Chung, Choon Hee; Kim, Hyeon Soo.

In: Journal of Cellular and Molecular Medicine, Vol. 19, No. 3, 01.01.2015, p. 620-629.

Research output: Contribution to journalArticle

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AU - Kim, Su Jin

AU - Kim, Hong Min

AU - Lee, Eun Soo

AU - Kim, Nami

AU - Lee, Jung Ok

AU - Lee, Hye Jeong

AU - Park, Na Yeon

AU - Jo, Joo Yeon

AU - Ham, Bo Young

AU - Han, Si Hyun

AU - Park, Sun Hwa

AU - Chung, Choon Hee

AU - Kim, Hyeon Soo

PY - 2015/1/1

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