Abstract
Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 469-476 |
| Number of pages | 8 |
| Journal | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Volume | 126 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Dec |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Pathology and Forensic Medicine
- Dentistry (miscellaneous)
- Radiology Nuclear Medicine and imaging
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Delayed bone healing by collagen membrane in early phase of 4 weeks. / Lee, Jungtae; Lee, Dajung; Oh, Seo Eun; Park, Kyeong Mee; Hu, Kyung Seok; Kim, Sungtae.
In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 126, No. 6, 12.2018, p. 469-476.Research output: Contribution to journal › Article
TY - JOUR
T1 - Delayed bone healing by collagen membrane in early phase of 4 weeks
AU - Lee, Jungtae
AU - Lee, Dajung
AU - Oh, Seo Eun
AU - Park, Kyeong Mee
AU - Hu, Kyung Seok
AU - Kim, Sungtae
PY - 2018/12
Y1 - 2018/12
N2 - Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.
AB - Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.
UR - http://www.scopus.com/inward/record.url?scp=85054103612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054103612&partnerID=8YFLogxK
U2 - 10.1016/j.oooo.2018.06.010
DO - 10.1016/j.oooo.2018.06.010
M3 - Article
C2 - 30274734
AN - SCOPUS:85054103612
VL - 126
SP - 469
EP - 476
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
SN - 2212-4403
IS - 6
ER -