Delayed bone healing by collagen membrane in early phase of 4 weeks

Jungtae Lee, Dajung Lee, Seo Eun Oh, Kyeong Mee Park, Kyung Seok Hu, Sungtae Kim

Research output: Contribution to journalArticle

Abstract

Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume126
Issue number6
DOIs
Publication statusPublished - 2018 Dec

Fingerprint

Bone Regeneration
Collagen
Bone and Bones
Membranes
Radiotherapy
Parietal Bone
Aftercare
Osteocalcin
Osteoclasts
Osteogenesis
Connective Tissue
Epithelium
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Lee, Jungtae ; Lee, Dajung ; Oh, Seo Eun ; Park, Kyeong Mee ; Hu, Kyung Seok ; Kim, Sungtae. / Delayed bone healing by collagen membrane in early phase of 4 weeks. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2018 ; Vol. 126, No. 6. pp. 469-476.
@article{e76c06c9a5b540aca8be448f92cf6d36,
title = "Delayed bone healing by collagen membrane in early phase of 4 weeks",
abstract = "Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.",
author = "Jungtae Lee and Dajung Lee and Oh, {Seo Eun} and Park, {Kyeong Mee} and Hu, {Kyung Seok} and Sungtae Kim",
year = "2018",
month = "12",
doi = "10.1016/j.oooo.2018.06.010",
language = "English",
volume = "126",
pages = "469--476",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "6",

}

Delayed bone healing by collagen membrane in early phase of 4 weeks. / Lee, Jungtae; Lee, Dajung; Oh, Seo Eun; Park, Kyeong Mee; Hu, Kyung Seok; Kim, Sungtae.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 126, No. 6, 12.2018, p. 469-476.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Delayed bone healing by collagen membrane in early phase of 4 weeks

AU - Lee, Jungtae

AU - Lee, Dajung

AU - Oh, Seo Eun

AU - Park, Kyeong Mee

AU - Hu, Kyung Seok

AU - Kim, Sungtae

PY - 2018/12

Y1 - 2018/12

N2 - Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.

AB - Objective: Barrier membranes are important in maintaining space in guided bone regeneration process by preventing downgrowth of epithelial or connective tissue. In this study, the effects of resorbable membranes during the early stages of bone regeneration in rats with impaired bone healing capacity were investigated. Study Design: Twenty-eight rats were selected for this study. Half of the animals were selected for radiation therapy before surgical procedure (G3, G4). Animals were assigned into 4 groups (G1–G4). A circular defect was created in the central parietal bone. It was covered with resorbable membrane in G2 and G4. After 4 weeks, the animals were sacrificed. Results: At week 4, the new bone formation was observed around the margin of old bone in G1, G2 and G4 groups. Osteoclast was most abundant in the G1 group (18.3 ± 7.7) and least abundant in the G4 group (7.9 ± 4.7). The mean of osteocalcin levels in blood was the highest in the G2 group and lowest in the G3 group. Only G4 group showed significant difference in Runx2 levels between before-treatment and after- treatment. Conclusions: Bone healing is adversely affected after radiation therapy. In addition, resorbable membranes can delay healing in the early stages of bone regeneration.

UR - http://www.scopus.com/inward/record.url?scp=85054103612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054103612&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2018.06.010

DO - 10.1016/j.oooo.2018.06.010

M3 - Article

C2 - 30274734

AN - SCOPUS:85054103612

VL - 126

SP - 469

EP - 476

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 6

ER -