Delayed enhancement magnetic resonance imaging is a significant prognostic factor in patients with non-ischemic cardiomyopathy

Jung Rae Cho, Sungha Park, Byoung Wook Choi, Seok Min Kang, Jong Won Ha, Namsik Chung, Kyu Ok Choe, Seung Yun Cho, Se Joong Rim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Delayed enhancement (DE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial fibrosis. The absence of DE in CMR is a predictor of left ventricular (LV) functional improvement in patients with non-ischemic cardiomyopathy (NICM), so in the present study it was investigated whether presence of DE has prognostic significance in patients with NICM at long-term follow-up. Methods and Results: The 79 patients (56.4±13.5 years, 48 males) with NICM (LV ejection fraction <35%, no significant coronary artery disease) were monitored for occurrence of cardiac events. CMR was performed to assess DE. Cardiac events were defined as rehospitalization (because of worsening of heart failure), cardiac transplantation or death. There were 37 patients without and 42 patients with DE. The mean follow-up duration was 19±10 months. There was 1 event (2.7%, 1 rehospitalization) in the DE (-) group, whereas 13 events (30.9%, 1 death, 1 transplantation, 11 rehospitalizations) occurred in the DE (+) group. The event-free survival was significantly longer in the DE (-) group than in the DE (+) group (38.9±1.0 vs 28.4±2.7 months, P<0.01). Multivariate regression analysis revealed that presence of DE was the most potent, independent predictor of cardiac events (hazard ratio 8.06, confidence interval 1.03±63.41, P<0.05). Conclusions: The presence of DE in CMR is a significant predictor of future cardiac events in patients with NICM.

Original languageEnglish
Pages (from-to)476-483
Number of pages8
JournalCirculation Journal
Volume74
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

Fingerprint

Cardiomyopathies
Magnetic Resonance Imaging
Heart Transplantation
Stroke Volume
Disease-Free Survival
Coronary Artery Disease
Fibrosis
Multivariate Analysis
Heart Failure
Transplantation
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Cho, Jung Rae ; Park, Sungha ; Choi, Byoung Wook ; Kang, Seok Min ; Ha, Jong Won ; Chung, Namsik ; Choe, Kyu Ok ; Cho, Seung Yun ; Rim, Se Joong. / Delayed enhancement magnetic resonance imaging is a significant prognostic factor in patients with non-ischemic cardiomyopathy. In: Circulation Journal. 2010 ; Vol. 74, No. 3. pp. 476-483.
@article{01878600655343de89aa4ac889d48c9f,
title = "Delayed enhancement magnetic resonance imaging is a significant prognostic factor in patients with non-ischemic cardiomyopathy",
abstract = "Background: Delayed enhancement (DE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial fibrosis. The absence of DE in CMR is a predictor of left ventricular (LV) functional improvement in patients with non-ischemic cardiomyopathy (NICM), so in the present study it was investigated whether presence of DE has prognostic significance in patients with NICM at long-term follow-up. Methods and Results: The 79 patients (56.4±13.5 years, 48 males) with NICM (LV ejection fraction <35{\%}, no significant coronary artery disease) were monitored for occurrence of cardiac events. CMR was performed to assess DE. Cardiac events were defined as rehospitalization (because of worsening of heart failure), cardiac transplantation or death. There were 37 patients without and 42 patients with DE. The mean follow-up duration was 19±10 months. There was 1 event (2.7{\%}, 1 rehospitalization) in the DE (-) group, whereas 13 events (30.9{\%}, 1 death, 1 transplantation, 11 rehospitalizations) occurred in the DE (+) group. The event-free survival was significantly longer in the DE (-) group than in the DE (+) group (38.9±1.0 vs 28.4±2.7 months, P<0.01). Multivariate regression analysis revealed that presence of DE was the most potent, independent predictor of cardiac events (hazard ratio 8.06, confidence interval 1.03±63.41, P<0.05). Conclusions: The presence of DE in CMR is a significant predictor of future cardiac events in patients with NICM.",
author = "Cho, {Jung Rae} and Sungha Park and Choi, {Byoung Wook} and Kang, {Seok Min} and Ha, {Jong Won} and Namsik Chung and Choe, {Kyu Ok} and Cho, {Seung Yun} and Rim, {Se Joong}",
year = "2010",
month = "3",
day = "1",
doi = "10.1253/circj.CJ-09-0446",
language = "English",
volume = "74",
pages = "476--483",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "3",

}

Delayed enhancement magnetic resonance imaging is a significant prognostic factor in patients with non-ischemic cardiomyopathy. / Cho, Jung Rae; Park, Sungha; Choi, Byoung Wook; Kang, Seok Min; Ha, Jong Won; Chung, Namsik; Choe, Kyu Ok; Cho, Seung Yun; Rim, Se Joong.

In: Circulation Journal, Vol. 74, No. 3, 01.03.2010, p. 476-483.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Delayed enhancement magnetic resonance imaging is a significant prognostic factor in patients with non-ischemic cardiomyopathy

AU - Cho, Jung Rae

AU - Park, Sungha

AU - Choi, Byoung Wook

AU - Kang, Seok Min

AU - Ha, Jong Won

AU - Chung, Namsik

AU - Choe, Kyu Ok

AU - Cho, Seung Yun

AU - Rim, Se Joong

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Background: Delayed enhancement (DE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial fibrosis. The absence of DE in CMR is a predictor of left ventricular (LV) functional improvement in patients with non-ischemic cardiomyopathy (NICM), so in the present study it was investigated whether presence of DE has prognostic significance in patients with NICM at long-term follow-up. Methods and Results: The 79 patients (56.4±13.5 years, 48 males) with NICM (LV ejection fraction <35%, no significant coronary artery disease) were monitored for occurrence of cardiac events. CMR was performed to assess DE. Cardiac events were defined as rehospitalization (because of worsening of heart failure), cardiac transplantation or death. There were 37 patients without and 42 patients with DE. The mean follow-up duration was 19±10 months. There was 1 event (2.7%, 1 rehospitalization) in the DE (-) group, whereas 13 events (30.9%, 1 death, 1 transplantation, 11 rehospitalizations) occurred in the DE (+) group. The event-free survival was significantly longer in the DE (-) group than in the DE (+) group (38.9±1.0 vs 28.4±2.7 months, P<0.01). Multivariate regression analysis revealed that presence of DE was the most potent, independent predictor of cardiac events (hazard ratio 8.06, confidence interval 1.03±63.41, P<0.05). Conclusions: The presence of DE in CMR is a significant predictor of future cardiac events in patients with NICM.

AB - Background: Delayed enhancement (DE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial fibrosis. The absence of DE in CMR is a predictor of left ventricular (LV) functional improvement in patients with non-ischemic cardiomyopathy (NICM), so in the present study it was investigated whether presence of DE has prognostic significance in patients with NICM at long-term follow-up. Methods and Results: The 79 patients (56.4±13.5 years, 48 males) with NICM (LV ejection fraction <35%, no significant coronary artery disease) were monitored for occurrence of cardiac events. CMR was performed to assess DE. Cardiac events were defined as rehospitalization (because of worsening of heart failure), cardiac transplantation or death. There were 37 patients without and 42 patients with DE. The mean follow-up duration was 19±10 months. There was 1 event (2.7%, 1 rehospitalization) in the DE (-) group, whereas 13 events (30.9%, 1 death, 1 transplantation, 11 rehospitalizations) occurred in the DE (+) group. The event-free survival was significantly longer in the DE (-) group than in the DE (+) group (38.9±1.0 vs 28.4±2.7 months, P<0.01). Multivariate regression analysis revealed that presence of DE was the most potent, independent predictor of cardiac events (hazard ratio 8.06, confidence interval 1.03±63.41, P<0.05). Conclusions: The presence of DE in CMR is a significant predictor of future cardiac events in patients with NICM.

UR - http://www.scopus.com/inward/record.url?scp=77649226322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649226322&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-09-0446

DO - 10.1253/circj.CJ-09-0446

M3 - Article

C2 - 20118568

AN - SCOPUS:77649226322

VL - 74

SP - 476

EP - 483

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 3

ER -