Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia

Hye Won Kim, Ji Hyun Yoon, Sung Joon Jin, Sun Bean Kim, Nam Su Ku, Su Jin Jeong, Sang Hoon Han, JunYong Choi, June Myung Kim, Young Goo Song

Research output: Contribution to journalArticle

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Abstract

Background: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. Materials and Methods: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. Results: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6% (OR: 305.18, 95% CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DNday 1 (OR: 77.77, 95% CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6% and DN-day 3 ≥ DN-day 1 was most predictive early mortality. Conclusions: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.

Original languageEnglish
Pages (from-to)94-102
Number of pages9
JournalInfection and Chemotherapy
Volume46
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Bacteremia
Neutrophils
Mortality
Odds Ratio
Confidence Intervals
Organ Dysfunction Scores
Republic of Korea
Hematology
Tertiary Care Centers
Sepsis
Multivariate Analysis
Retrospective Studies
Logistic Models
Morbidity

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Kim, H. W., Yoon, J. H., Jin, S. J., Kim, S. B., Ku, N. S., Jeong, S. J., ... Song, Y. G. (2014). Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia. Infection and Chemotherapy, 46(2), 94-102. https://doi.org/10.3947/ic.2014.46.2.94
Kim, Hye Won ; Yoon, Ji Hyun ; Jin, Sung Joon ; Kim, Sun Bean ; Ku, Nam Su ; Jeong, Su Jin ; Han, Sang Hoon ; Choi, JunYong ; Kim, June Myung ; Song, Young Goo. / Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia. In: Infection and Chemotherapy. 2014 ; Vol. 46, No. 2. pp. 94-102.
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abstract = "Background: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. Materials and Methods: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. Results: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95{\%} confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6{\%} (OR: 305.18, 95{\%} CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DNday 1 (OR: 77.77, 95{\%} CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6{\%} and DN-day 3 ≥ DN-day 1 was most predictive early mortality. Conclusions: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.",
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Kim, HW, Yoon, JH, Jin, SJ, Kim, SB, Ku, NS, Jeong, SJ, Han, SH, Choi, J, Kim, JM & Song, YG 2014, 'Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia', Infection and Chemotherapy, vol. 46, no. 2, pp. 94-102. https://doi.org/10.3947/ic.2014.46.2.94

Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia. / Kim, Hye Won; Yoon, Ji Hyun; Jin, Sung Joon; Kim, Sun Bean; Ku, Nam Su; Jeong, Su Jin; Han, Sang Hoon; Choi, JunYong; Kim, June Myung; Song, Young Goo.

In: Infection and Chemotherapy, Vol. 46, No. 2, 01.01.2014, p. 94-102.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia

AU - Kim, Hye Won

AU - Yoon, Ji Hyun

AU - Jin, Sung Joon

AU - Kim, Sun Bean

AU - Ku, Nam Su

AU - Jeong, Su Jin

AU - Han, Sang Hoon

AU - Choi, JunYong

AU - Kim, June Myung

AU - Song, Young Goo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. Materials and Methods: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. Results: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6% (OR: 305.18, 95% CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DNday 1 (OR: 77.77, 95% CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6% and DN-day 3 ≥ DN-day 1 was most predictive early mortality. Conclusions: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.

AB - Background: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. Materials and Methods: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. Results: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6% (OR: 305.18, 95% CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DNday 1 (OR: 77.77, 95% CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6% and DN-day 3 ≥ DN-day 1 was most predictive early mortality. Conclusions: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.

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