Delta neutrophil index

Could it predict mortality in patients with bacteraemia?

Hye Won Kim, Su Ku, Su Jin Jeong, Sung Joon Jin, Sang Hoon Han, JunYong Choi, June Myung Kim, Young Goo Song

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Despite advances in therapy, sepsis still has a high mortality rate. To improve the treatment outcome, early diagnosis and treatment is essential, as reflected in many publications about biomarkers for sepsis. Recent models of automatic cell analyzers provide the delta neutrophil index (DN), which corresponds to the fraction of immature granulocytes in circulating blood. This study investigated DN as a prognostic marker in patients with bacteraemia. Methods: We retrospectively collected data on adult patients with bacteraemia admitted to an urban hospital between November 2009 and April 2010. The DN was measured at the onset of bacteraemia and at 24 and 72 h later. Factors associated with 28-day mortality were assessed using logistic regression. Results: A total of 102 patients were included in the analysis, and 24 patients died within 28 days. In the univariate analysis, appropriate antibiotic treatment, multidrug-resistant bacterial infection, history of intensive care unit (ICU) stay before the onset of bacteraemia, healthcare-associated infection, DN at 72 h after the onset of bacteraemia (DN-72 h), and platelet count at the onset of bacteraemia were significantly associated with survival. In multivariate analysis, DN-72 h (odds ratio (OR) 1.246, 95% confidence interval (CI) 1.0301.508; p 0.023), platelet count at the onset of bacteraemia (OR 0.986, 95% CI 0.9770.995; p 0.003), and history of ICU stay before the onset of bacteraemia (OR 4.907, 95% CI 1.04523.051; p 0.044) were the independent factors associated with survival. Conclusion: DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Volume44
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Bacteremia
Neutrophils
Mortality
Odds Ratio
Confidence Intervals
Platelet Count
Intensive Care Units
Sepsis
Survival
Urban Hospitals
Cross Infection
Bacterial Infections
Granulocytes
Publications
Early Diagnosis
Therapeutics
Multivariate Analysis
Biomarkers
Logistic Models
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Kim, Hye Won ; Ku, Su ; Jeong, Su Jin ; Jin, Sung Joon ; Han, Sang Hoon ; Choi, JunYong ; Kim, June Myung ; Song, Young Goo. / Delta neutrophil index : Could it predict mortality in patients with bacteraemia?. In: Scandinavian Journal of Infectious Diseases. 2012 ; Vol. 44, No. 7. pp. 475-480.
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title = "Delta neutrophil index: Could it predict mortality in patients with bacteraemia?",
abstract = "Background: Despite advances in therapy, sepsis still has a high mortality rate. To improve the treatment outcome, early diagnosis and treatment is essential, as reflected in many publications about biomarkers for sepsis. Recent models of automatic cell analyzers provide the delta neutrophil index (DN), which corresponds to the fraction of immature granulocytes in circulating blood. This study investigated DN as a prognostic marker in patients with bacteraemia. Methods: We retrospectively collected data on adult patients with bacteraemia admitted to an urban hospital between November 2009 and April 2010. The DN was measured at the onset of bacteraemia and at 24 and 72 h later. Factors associated with 28-day mortality were assessed using logistic regression. Results: A total of 102 patients were included in the analysis, and 24 patients died within 28 days. In the univariate analysis, appropriate antibiotic treatment, multidrug-resistant bacterial infection, history of intensive care unit (ICU) stay before the onset of bacteraemia, healthcare-associated infection, DN at 72 h after the onset of bacteraemia (DN-72 h), and platelet count at the onset of bacteraemia were significantly associated with survival. In multivariate analysis, DN-72 h (odds ratio (OR) 1.246, 95{\%} confidence interval (CI) 1.0301.508; p 0.023), platelet count at the onset of bacteraemia (OR 0.986, 95{\%} CI 0.9770.995; p 0.003), and history of ICU stay before the onset of bacteraemia (OR 4.907, 95{\%} CI 1.04523.051; p 0.044) were the independent factors associated with survival. Conclusion: DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.",
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Delta neutrophil index : Could it predict mortality in patients with bacteraemia? / Kim, Hye Won; Ku, Su; Jeong, Su Jin; Jin, Sung Joon; Han, Sang Hoon; Choi, JunYong; Kim, June Myung; Song, Young Goo.

In: Scandinavian Journal of Infectious Diseases, Vol. 44, No. 7, 01.07.2012, p. 475-480.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Delta neutrophil index

T2 - Could it predict mortality in patients with bacteraemia?

AU - Kim, Hye Won

AU - Ku, Su

AU - Jeong, Su Jin

AU - Jin, Sung Joon

AU - Han, Sang Hoon

AU - Choi, JunYong

AU - Kim, June Myung

AU - Song, Young Goo

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Background: Despite advances in therapy, sepsis still has a high mortality rate. To improve the treatment outcome, early diagnosis and treatment is essential, as reflected in many publications about biomarkers for sepsis. Recent models of automatic cell analyzers provide the delta neutrophil index (DN), which corresponds to the fraction of immature granulocytes in circulating blood. This study investigated DN as a prognostic marker in patients with bacteraemia. Methods: We retrospectively collected data on adult patients with bacteraemia admitted to an urban hospital between November 2009 and April 2010. The DN was measured at the onset of bacteraemia and at 24 and 72 h later. Factors associated with 28-day mortality were assessed using logistic regression. Results: A total of 102 patients were included in the analysis, and 24 patients died within 28 days. In the univariate analysis, appropriate antibiotic treatment, multidrug-resistant bacterial infection, history of intensive care unit (ICU) stay before the onset of bacteraemia, healthcare-associated infection, DN at 72 h after the onset of bacteraemia (DN-72 h), and platelet count at the onset of bacteraemia were significantly associated with survival. In multivariate analysis, DN-72 h (odds ratio (OR) 1.246, 95% confidence interval (CI) 1.0301.508; p 0.023), platelet count at the onset of bacteraemia (OR 0.986, 95% CI 0.9770.995; p 0.003), and history of ICU stay before the onset of bacteraemia (OR 4.907, 95% CI 1.04523.051; p 0.044) were the independent factors associated with survival. Conclusion: DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.

AB - Background: Despite advances in therapy, sepsis still has a high mortality rate. To improve the treatment outcome, early diagnosis and treatment is essential, as reflected in many publications about biomarkers for sepsis. Recent models of automatic cell analyzers provide the delta neutrophil index (DN), which corresponds to the fraction of immature granulocytes in circulating blood. This study investigated DN as a prognostic marker in patients with bacteraemia. Methods: We retrospectively collected data on adult patients with bacteraemia admitted to an urban hospital between November 2009 and April 2010. The DN was measured at the onset of bacteraemia and at 24 and 72 h later. Factors associated with 28-day mortality were assessed using logistic regression. Results: A total of 102 patients were included in the analysis, and 24 patients died within 28 days. In the univariate analysis, appropriate antibiotic treatment, multidrug-resistant bacterial infection, history of intensive care unit (ICU) stay before the onset of bacteraemia, healthcare-associated infection, DN at 72 h after the onset of bacteraemia (DN-72 h), and platelet count at the onset of bacteraemia were significantly associated with survival. In multivariate analysis, DN-72 h (odds ratio (OR) 1.246, 95% confidence interval (CI) 1.0301.508; p 0.023), platelet count at the onset of bacteraemia (OR 0.986, 95% CI 0.9770.995; p 0.003), and history of ICU stay before the onset of bacteraemia (OR 4.907, 95% CI 1.04523.051; p 0.044) were the independent factors associated with survival. Conclusion: DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.

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