Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

In Mi Han, Chang Yun Yoon, Dong Ho Shin, Youn Kyung Kee, Seung Gyu Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, SeungHyeok Han, Shin-Wook Kang, TaeHyun Yoo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). Method: This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients. Results: Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036). Conclusion: This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.

Original languageEnglish
Article number94
JournalBMC Nephrology
Volume18
Issue number1
DOIs
Publication statusPublished - 2017 Mar 20

Fingerprint

Renal Replacement Therapy
Acute Kidney Injury
Neutrophils
Mortality
Proportional Hazards Models
Organ Dysfunction Scores
APACHE
Granulocytes
Sepsis
Confidence Intervals
Survival
Infection

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Han, In Mi ; Yoon, Chang Yun ; Shin, Dong Ho ; Kee, Youn Kyung ; Han, Seung Gyu ; Kwon, Young Eun ; Park, Kyoung Sook ; Lee, Mi Jung ; Oh, Hyung Jung ; Park, Jung Tak ; Han, SeungHyeok ; Kang, Shin-Wook ; Yoo, TaeHyun. / Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy. In: BMC Nephrology. 2017 ; Vol. 18, No. 1.
@article{cd885d6568b8459983b3cbc4e27d92e0,
title = "Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy",
abstract = "Background: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). Method: This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0{\%}; intermediate, 3.6-12.0{\%}; low, < 3.6{\%}). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients. Results: Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95{\%} confidence interval, 1.001-1.019; P = 0.036). Conclusion: This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.",
author = "Han, {In Mi} and Yoon, {Chang Yun} and Shin, {Dong Ho} and Kee, {Youn Kyung} and Han, {Seung Gyu} and Kwon, {Young Eun} and Park, {Kyoung Sook} and Lee, {Mi Jung} and Oh, {Hyung Jung} and Park, {Jung Tak} and SeungHyeok Han and Shin-Wook Kang and TaeHyun Yoo",
year = "2017",
month = "3",
day = "20",
doi = "10.1186/s12882-017-0507-8",
language = "English",
volume = "18",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy. / Han, In Mi; Yoon, Chang Yun; Shin, Dong Ho; Kee, Youn Kyung; Han, Seung Gyu; Kwon, Young Eun; Park, Kyoung Sook; Lee, Mi Jung; Oh, Hyung Jung; Park, Jung Tak; Han, SeungHyeok; Kang, Shin-Wook; Yoo, TaeHyun.

In: BMC Nephrology, Vol. 18, No. 1, 94, 20.03.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

AU - Han, In Mi

AU - Yoon, Chang Yun

AU - Shin, Dong Ho

AU - Kee, Youn Kyung

AU - Han, Seung Gyu

AU - Kwon, Young Eun

AU - Park, Kyoung Sook

AU - Lee, Mi Jung

AU - Oh, Hyung Jung

AU - Park, Jung Tak

AU - Han, SeungHyeok

AU - Kang, Shin-Wook

AU - Yoo, TaeHyun

PY - 2017/3/20

Y1 - 2017/3/20

N2 - Background: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). Method: This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients. Results: Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036). Conclusion: This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.

AB - Background: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). Method: This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients. Results: Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036). Conclusion: This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.

UR - http://www.scopus.com/inward/record.url?scp=85015783371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015783371&partnerID=8YFLogxK

U2 - 10.1186/s12882-017-0507-8

DO - 10.1186/s12882-017-0507-8

M3 - Article

VL - 18

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 94

ER -