Dendrimer-mediated multivalent binding for the enhanced capture of tumor cells

Ja Hye Myung, Khyati A. Gajjar, Jelena Saric, David T. Eddington, Seungpyo Hong

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

A naturally occurring multivalent binding effect is manipulated by engineering cell capture surfaces using dendrimers. The enhanced binding through the multivalent effect significantly improves detection of tumor cells. This improvement can be potentially translated into clinically significant detection of circulating tumor cells from the blood of cancer patients.

Original languageEnglish
Pages (from-to)11769-11772
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number49
DOIs
Publication statusPublished - 2011 Dec 2

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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