Dendritic nanomaterials have attracted a great deal of scientific interest for use in various biomedical applications primarily due to their well-defined structure and capacity for multifunctionalization. In this chapter, we present a comprehensive overview of the recent advances in various dendrimers and their modified dendritic materials with a particular focus on their applications such as drug delivery, gene delivery, diagnostics and prognostics, and detoxification/ prophylaxis. We also discuss the fundamentals of the biological interactions of dendritic nanomaterials in regard to non-specific cell interactions, multivalent binding, stimuli-responsive processes, and biodistribution. In addition, this chapter highlights the current drawbacks of dendrimers that have hindered their rapid clinical translation and introduce recent approaches to overcoming these challenges.
|Title of host publication||Biomedical Engineering|
|Subtitle of host publication||Frontier Research and Converging Technologies|
|Publisher||Springer International Publishing|
|Number of pages||35|
|Publication status||Published - 2015 Jul 23|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)