Dendritic nanomaterials for therapeutic and diagnostic applications

Ja Hye Myung, Kevin A. Tam, Seungpyo Hong

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Dendritic nanomaterials have attracted a great deal of scientific interest for use in various biomedical applications primarily due to their well-defined structure and capacity for multifunctionalization. In this chapter, we present a comprehensive overview of the recent advances in various dendrimers and their modified dendritic materials with a particular focus on their applications such as drug delivery, gene delivery, diagnostics and prognostics, and detoxification/ prophylaxis. We also discuss the fundamentals of the biological interactions of dendritic nanomaterials in regard to non-specific cell interactions, multivalent binding, stimuli-responsive processes, and biodistribution. In addition, this chapter highlights the current drawbacks of dendrimers that have hindered their rapid clinical translation and introduce recent approaches to overcoming these challenges.

Original languageEnglish
Title of host publicationBiomedical Engineering
Subtitle of host publicationFrontier Research and Converging Technologies
PublisherSpringer International Publishing
Pages41-75
Number of pages35
Volume9
ISBN (Electronic)9783319218137
ISBN (Print)9783319218120
DOIs
Publication statusPublished - 2015 Jul 23

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Medicine(all)
  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Myung, J. H., Tam, K. A., & Hong, S. (2015). Dendritic nanomaterials for therapeutic and diagnostic applications. In Biomedical Engineering: Frontier Research and Converging Technologies (Vol. 9, pp. 41-75). Springer International Publishing. https://doi.org/10.1007/978-3-319-21813-7_3