Dendritic nanoparticles: The next generation of nanocarriers?

Ryan M. Pearson, Suhair Sunoqrot, Hao Jui Hsu, Jin Woo Bae, Seungpyo Hong

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Dendritic polymers have attracted a great deal of scientific interest due to their well-defined unique structure and capability to be multifunctionalized. Here we present a comprehensive overview of various dendrimer-based nanomaterials that are currently being investigated for therapeutic delivery and diagnostic applications. Through a critical review of the old and new dendritic designs, we highlight the advantages and disadvantages of these systems and their structure-biological property relationships. This article also focuses on the major challenges facing the clinical translation of these nanomaterials and how these challenges are being (or should be) addressed, which will greatly benefit the overall progress of dendritic materials for theranostics.

Original languageEnglish
Pages (from-to)941-959
Number of pages19
JournalTherapeutic Delivery
Volume3
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this