Dendron-mediated self-assembly of highly PEGylated block copolymers: A modular nanocarrier platform

Jin Woo Bae; Ryan M. Pearson; Niladri Patra; Suhair Sunoqrot; Lela Vuković; Petr Král; Seungpyo Hong

doi:10.1039/c1cc14331j

Dendron-mediated self-assembly of highly PEGylated block copolymers: A modular nanocarrier platform

Jin Woo Bae, Ryan M. Pearson, Niladri Patra, Suhair Sunoqrot, Lela Vuković, Petr Král, Seungpyo Hong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

Original language	English
Pages (from-to)	10302-10304
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	37
DOIs	https://doi.org/10.1039/c1cc14331j
Publication status	Published - 2011 Oct 7

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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T2 - A modular nanocarrier platform

AU - Bae, Jin Woo

AU - Pearson, Ryan M.

AU - Patra, Niladri

AU - Sunoqrot, Suhair

AU - Vuković, Lela

AU - Král, Petr

AU - Hong, Seungpyo

PY - 2011/10/7

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AB - PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

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Dendron-mediated self-assembly of highly PEGylated block copolymers: A modular nanocarrier platform

Abstract

All Science Journal Classification (ASJC) codes

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