Dense deposit disease in korean children: A multicenter clinicopathologic study

Se Jin Park, Yong Jin Kim, Tae Sun Ha, Beom Jin Lim, Hyeon Joo Jeong, Yong Hoon Park, Dae Yeol Lee, Pyung Kil Kim, Kyo Sun Kim, Woo Yeong Chung, Jae Il Shin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously published data on 14 American children with DDD. Korean children had lower 24-hr urine protein excretion and higher serum albumin levels than American children. The light microscopic findings revealed that a higher percentage of Korean children had membranoproliferative glomerulonephritis patterns (Korean, 77.8%; American, 28.6%, P = 0.036), whereas a higher percentage of American children had crescents (Korean, 0%; American, 78.6%, P < 0.001). The findings from the electron microscopy revealed that Korean children were more likely to have segmental electron dense deposits in the lamina densa of the glomerular basement membrane (Korean, 100%; American, 28.6%, P = 0.002); mesangial deposit was more frequent in American children (Korean, 66.7%; American, 100%, P = 0.047). The histological findings revealed that Korean children with DDD were more likely to show membranoproliferative glomerulonephritis patterns than American children. The degree of proteinuria and hypoalbuminemia was milder in Korean children than American children.

Original languageEnglish
Pages (from-to)1215-1221
Number of pages7
JournalJournal of Korean medical science
Volume27
Issue number10
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Membranoproliferative Glomerulonephritis
Multicenter Studies
Hypoalbuminemia
Glomerular Basement Membrane
Asian Americans
Korea
Proteinuria
Serum Albumin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Se Jin ; Kim, Yong Jin ; Ha, Tae Sun ; Lim, Beom Jin ; Jeong, Hyeon Joo ; Park, Yong Hoon ; Lee, Dae Yeol ; Kim, Pyung Kil ; Kim, Kyo Sun ; Chung, Woo Yeong ; Shin, Jae Il. / Dense deposit disease in korean children : A multicenter clinicopathologic study. In: Journal of Korean medical science. 2012 ; Vol. 27, No. 10. pp. 1215-1221.
@article{d677aa4101d44a838543abc0696eb6a8,
title = "Dense deposit disease in korean children: A multicenter clinicopathologic study",
abstract = "The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously published data on 14 American children with DDD. Korean children had lower 24-hr urine protein excretion and higher serum albumin levels than American children. The light microscopic findings revealed that a higher percentage of Korean children had membranoproliferative glomerulonephritis patterns (Korean, 77.8{\%}; American, 28.6{\%}, P = 0.036), whereas a higher percentage of American children had crescents (Korean, 0{\%}; American, 78.6{\%}, P < 0.001). The findings from the electron microscopy revealed that Korean children were more likely to have segmental electron dense deposits in the lamina densa of the glomerular basement membrane (Korean, 100{\%}; American, 28.6{\%}, P = 0.002); mesangial deposit was more frequent in American children (Korean, 66.7{\%}; American, 100{\%}, P = 0.047). The histological findings revealed that Korean children with DDD were more likely to show membranoproliferative glomerulonephritis patterns than American children. The degree of proteinuria and hypoalbuminemia was milder in Korean children than American children.",
author = "Park, {Se Jin} and Kim, {Yong Jin} and Ha, {Tae Sun} and Lim, {Beom Jin} and Jeong, {Hyeon Joo} and Park, {Yong Hoon} and Lee, {Dae Yeol} and Kim, {Pyung Kil} and Kim, {Kyo Sun} and Chung, {Woo Yeong} and Shin, {Jae Il}",
year = "2012",
month = "12",
day = "1",
doi = "10.3346/jkms.2012.27.10.1215",
language = "English",
volume = "27",
pages = "1215--1221",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "10",

}

Park, SJ, Kim, YJ, Ha, TS, Lim, BJ, Jeong, HJ, Park, YH, Lee, DY, Kim, PK, Kim, KS, Chung, WY & Shin, JI 2012, 'Dense deposit disease in korean children: A multicenter clinicopathologic study', Journal of Korean medical science, vol. 27, no. 10, pp. 1215-1221. https://doi.org/10.3346/jkms.2012.27.10.1215

Dense deposit disease in korean children : A multicenter clinicopathologic study. / Park, Se Jin; Kim, Yong Jin; Ha, Tae Sun; Lim, Beom Jin; Jeong, Hyeon Joo; Park, Yong Hoon; Lee, Dae Yeol; Kim, Pyung Kil; Kim, Kyo Sun; Chung, Woo Yeong; Shin, Jae Il.

In: Journal of Korean medical science, Vol. 27, No. 10, 01.12.2012, p. 1215-1221.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dense deposit disease in korean children

T2 - A multicenter clinicopathologic study

AU - Park, Se Jin

AU - Kim, Yong Jin

AU - Ha, Tae Sun

AU - Lim, Beom Jin

AU - Jeong, Hyeon Joo

AU - Park, Yong Hoon

AU - Lee, Dae Yeol

AU - Kim, Pyung Kil

AU - Kim, Kyo Sun

AU - Chung, Woo Yeong

AU - Shin, Jae Il

PY - 2012/12/1

Y1 - 2012/12/1

N2 - The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously published data on 14 American children with DDD. Korean children had lower 24-hr urine protein excretion and higher serum albumin levels than American children. The light microscopic findings revealed that a higher percentage of Korean children had membranoproliferative glomerulonephritis patterns (Korean, 77.8%; American, 28.6%, P = 0.036), whereas a higher percentage of American children had crescents (Korean, 0%; American, 78.6%, P < 0.001). The findings from the electron microscopy revealed that Korean children were more likely to have segmental electron dense deposits in the lamina densa of the glomerular basement membrane (Korean, 100%; American, 28.6%, P = 0.002); mesangial deposit was more frequent in American children (Korean, 66.7%; American, 100%, P = 0.047). The histological findings revealed that Korean children with DDD were more likely to show membranoproliferative glomerulonephritis patterns than American children. The degree of proteinuria and hypoalbuminemia was milder in Korean children than American children.

AB - The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously published data on 14 American children with DDD. Korean children had lower 24-hr urine protein excretion and higher serum albumin levels than American children. The light microscopic findings revealed that a higher percentage of Korean children had membranoproliferative glomerulonephritis patterns (Korean, 77.8%; American, 28.6%, P = 0.036), whereas a higher percentage of American children had crescents (Korean, 0%; American, 78.6%, P < 0.001). The findings from the electron microscopy revealed that Korean children were more likely to have segmental electron dense deposits in the lamina densa of the glomerular basement membrane (Korean, 100%; American, 28.6%, P = 0.002); mesangial deposit was more frequent in American children (Korean, 66.7%; American, 100%, P = 0.047). The histological findings revealed that Korean children with DDD were more likely to show membranoproliferative glomerulonephritis patterns than American children. The degree of proteinuria and hypoalbuminemia was milder in Korean children than American children.

UR - http://www.scopus.com/inward/record.url?scp=84872572817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872572817&partnerID=8YFLogxK

U2 - 10.3346/jkms.2012.27.10.1215

DO - 10.3346/jkms.2012.27.10.1215

M3 - Article

C2 - 23091320

AN - SCOPUS:84872572817

VL - 27

SP - 1215

EP - 1221

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 10

ER -