Dense deposit disease in korean children: A multicenter clinicopathologic study

Se Jin Park, Yong Jin Kim, Tae Sun Ha, Beom Jin Lim, Hyeon Joo Jeong, Yong Hoon Park, Dae Yeol Lee, Pyung Kil Kim, Kyo Sun Kim, Woo Yeong Chung, Jae Il Shin

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3 Citations (Scopus)

Abstract

The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously published data on 14 American children with DDD. Korean children had lower 24-hr urine protein excretion and higher serum albumin levels than American children. The light microscopic findings revealed that a higher percentage of Korean children had membranoproliferative glomerulonephritis patterns (Korean, 77.8%; American, 28.6%, P = 0.036), whereas a higher percentage of American children had crescents (Korean, 0%; American, 78.6%, P < 0.001). The findings from the electron microscopy revealed that Korean children were more likely to have segmental electron dense deposits in the lamina densa of the glomerular basement membrane (Korean, 100%; American, 28.6%, P = 0.002); mesangial deposit was more frequent in American children (Korean, 66.7%; American, 100%, P = 0.047). The histological findings revealed that Korean children with DDD were more likely to show membranoproliferative glomerulonephritis patterns than American children. The degree of proteinuria and hypoalbuminemia was milder in Korean children than American children.

Original languageEnglish
Pages (from-to)1215-1221
Number of pages7
JournalJournal of Korean medical science
Volume27
Issue number10
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Park, S. J., Kim, Y. J., Ha, T. S., Lim, B. J., Jeong, H. J., Park, Y. H., Lee, D. Y., Kim, P. K., Kim, K. S., Chung, W. Y., & Shin, J. I. (2012). Dense deposit disease in korean children: A multicenter clinicopathologic study. Journal of Korean medical science, 27(10), 1215-1221. https://doi.org/10.3346/jkms.2012.27.10.1215