Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophago-some formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and related metabolic diseases remains elusive. In this study, we show that adipocyte-specific Becn1 knockout mice develop severe lipodystrophy, leading to adipose tissue inflam-mation, hepatic steatosis, and insulin resistance. Ablation of Becn1 in adipocytes stimulates programmed cell death in a cell-autonomous manner, accompanied by elevated endoplasmic reticulum (ER) stress gene expression. Fur-thermore, we observed that Becn1 depletion sensitized mature adipocytes to ER stress, leading to accelerated cell death. Taken together, these data suggest that adi-pocyte Becn1 would serve as a crucial player for adipo-cyte survival and adipose tissue homeostasis.
Bibliographical noteFunding Information:
Funding. This work was supported by National Research Foundation of Korea grants funded by the Korean government (Ministry of Science and ICT, NRF-2020R1A3B2078617 to J.B.K. and 2018R1A2A1A05022746, 2020R1A4A1019063, and 2019R1I1A 01058338) and in part by the Brain Korea 21 PLUS Project for Medical Science. Duality of Interest. No potential conflicts of interest relevant to this article were reported.
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism