Depolarization signatures map gold nanorods within biological tissue

Norman Lippok, Martin Villiger, Alexandre Albanese, Eelco F.J. Meijer, Kwanghun Chung, Timothy P. Padera, Sangeeta N. Bhatia, Brett E. Bouma

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Owing to their electromagnetic properties, tunability and biocompatibility, gold nanorods are being investigated as multifunctional probes for a range of biomedical applications. However, detection beyond the reach of traditional fluorescence and two-photon approaches and quantitation of their concentration in biological tissue remain challenging tasks in microscopy. Here, we show how the size and aspect ratio that impart gold nanorods with their plasmonic properties also make them a source of entropy. We report on how depolarization can be exploited as a strategy to visualize gold nanorod diffusion and distribution in biologically relevant scenarios ex vivo, in vitro and in vivo. We identify a deterministic relation between depolarization and nanoparticle concentration. As a result, some of the most stringent experimental conditions can be relaxed, and susceptibility to artefacts is reduced, enabling microscopic and macroscopic applications.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalNature Photonics
Volume11
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Lippok, N., Villiger, M., Albanese, A., Meijer, E. F. J., Chung, K., Padera, T. P., Bhatia, S. N., & Bouma, B. E. (2017). Depolarization signatures map gold nanorods within biological tissue. Nature Photonics, 11(9), 583-588. https://doi.org/10.1038/nphoton.2017.128