Depth-resolved measurement of transient structural changes during action potential propagation

Taner Akkin, Chulmin Joo, Johannes F. De Boer

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We report noncontact optical measurement of fast transient structural changes in the crustacean nerve during action potential propagation without the need for exogenous chemicals or re.ection coatings. The technique, spectral domain optical coherence tomography, provides real-time cross-sectional images of the nerve with micron-scale resolution to select a specific region for functional assessment and interferometric phase sensitivity for subnanometer-scale motion detection. Noncontact optical measurements demonstrate nanometer-scale transient movement on a 1-ms timescale associated with action potential propagation in cray.sh and lobster nerves.

Original languageEnglish
Pages (from-to)1347-1353
Number of pages7
JournalBiophysical Journal
Volume93
Issue number4
DOIs
Publication statusPublished - 2007 Aug

All Science Journal Classification (ASJC) codes

  • Biophysics

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